PMID- 25687054
OWN - NLM
STAT- MEDLINE
DCOM- 20151016
LR  - 20181202
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 23
IP  - 1
DP  - 2015 Feb
TI  - [Elderly chronic lymphocytic leukemia combined with invasive aspergillosis 
      infection in one case].
PG  - 99-105
LID - 10.7534/j.issn.1009-2137.2015.01.019 [doi]
AB  - OBJECTIVE: This study was aimed to investigate the morphological, 
      immunophenotype, cytogenetic characteristics, clinical and therapy features in 
      one elderly patient with chronic lymphocytic leukemia (CLL) combined with 
      invasive aspergillose infection(IAI). METHODS: The morphological features of bone 
      marrow cells from patient were observed by light microscope, the immunophenotype 
      were detected by flow cytometry, the cytogenetic characteristics were assayed by 
      conventional chromosomal analysis and fluorescence in situ hybridization (FISH). 
      RESULTS: at onset of disease, the patient was diagnosed as B-CLL, Rai stage is 
      II. He was treated with a course of RF(fludarabine 50 mgx5, rituximab 600 mgx5) 
      chemotherapy, and achived complete remission (CR) lasting for five years, then 
      the patient was treated with multiple courses of chemotherapy and maintained at a 
      steady state of disease. After the last chemotherapy, this patient developed a 
      fever, his temperature fluctuated at 37.2-38.7 degrees C, the lung CT showed the presence 
      of massive shadow, repeated 1-3-beta-D-glucan test was positive,and he was 
      considered as invasive aspergillosis infection, voriconazole was intravenously 
      injected him for 2 months, his lung CT showed better efficacy. However, the 
      leukemia continued progress, his hemogram was extremely low, invasive 
      aspergillosis infection relapsed,voriconazole treatment was poor 
      effect,ultimately this patient died of the rapid progress of leukemia and 
      multiple organ invasive aspergillosis. Autopsy showed chronic lymphocytic 
      leukemia with multiple metastases and multiple organ invasive aspergillosis. 
      CONCLUSION: invasive aspergillosis is a serious complication for CLL 
      patients,once occurs, the prognosis is poor,so early diagnosis and prophylactic 
      antifungal therapy may reduce fungal infection complication.
FAU - Li, Bao-Ling
AU  - Li BL
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Li, Su-Xia
AU  - Li SX
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Wang, Tong-Min
AU  - Wang TM
AD  - Department of Burns and Plastic Surgery, The First Affiliated Hospital of Chinese 
      PLA General Hospital, Beijing 100048, China.
FAU - Zhu, Hong-Li
AU  - Zhu HL
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China. E-mail: bjzhl202_cn@ sina.com.
FAU - Wang, Hai-Tao
AU  - Wang HT
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China; Department of Hematology, The First Affiliated Hospital of Chinese PLA 
      General Hospital, Beijing 100048, China.
FAU - Li, Jie
AU  - Li J
AD  - Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China.
FAU - Zhai, Bing
AU  - Zhai B
AD  - Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, 
      China.
LA  - chi
PT  - Case Reports
PT  - Journal Article
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (Antibodies, Monoclonal, Murine-Derived)
RN  - 0 (Antifungal Agents)
RN  - 4F4X42SYQ6 (Rituximab)
RN  - FA2DM6879K (Vidarabine)
RN  - P2K93U8740 (fludarabine)
SB  - IM
MH  - Aged
MH  - Antibodies, Monoclonal, Murine-Derived
MH  - Antifungal Agents
MH  - Antineoplastic Combined Chemotherapy Protocols
MH  - *Aspergillosis
MH  - Flow Cytometry
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Leukemia, Lymphocytic, Chronic, B-Cell
MH  - Male
MH  - Remission Induction
MH  - Rituximab
MH  - Vidarabine/analogs & derivatives
EDAT- 2015/02/18 06:00
MHDA- 2015/10/17 06:00
CRDT- 2015/02/18 06:00
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2015/10/17 06:00 [medline]
AID - 1009-2137(2015)01-0099-07 [pii]
AID - 10.7534/j.issn.1009-2137.2015.01.019 [doi]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Feb;23(1):99-105. doi: 
      10.7534/j.issn.1009-2137.2015.01.019.