PMID- 25687386
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20220321
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 37
IP  - 4
DP  - 2015 May
TI  - The relationship between brain-derived neurotrophic factor levels, oxidative and 
      nitrosative stress and depressive symptoms: a study on peritoneal dialysis.
PG  - 722-6
LID - 10.3109/0886022X.2015.1011551 [doi]
AB  - BACKGROUND: Depression is one of the most commonly encountered psychiatric 
      problems in peritoneal dialysis (PD) patients. Our aim was to investigate the 
      associations between oxidative and nitrosative stress (O&NS) and brain-derived 
      neurotrophic factor (BDNF) in PD patients with elevated depressive symptoms 
      (EDS). METHODS: Eighty-three patients with PD and 84 healthy controls were 
      enrolled in this study. In PD patients, two subgroups were formed: 28 with and 55 
      without EDS. EDS were defined as a Beck Depression Inventory (BDI) score >/=17 in 
      patients. Serum malondialdehyde (MDA) erythrocyte, glutathione (GSH) levels 
      measured spectrophotometrically. Serum superoxide dismutase (SOD) activity, 
      nitric oxide (NO) and BDNF levels were determined by ELISA. RESULTS: While MDA 
      and NO levels were higher, levels of SOD, GSH and BDNF were lower in PD patients 
      compared to controls (p < 0.001). The patients with EDS had higher levels of MDA 
      and lower levels of BDNF as compared to those without EDS (p < 0.005). In linear 
      regression analysis, the BDNF levels were dependently associated with SOD levels 
      in PD patients (B: 0.274, p: 0.043). In addition, while a negative correlation 
      existed between BDI scores with BDNF levels (r = -0.312, p = 0.004), a positive 
      correlation was present between BDI scores and MDA levels (r = 0.320, p = 0.005) 
      in PD patients. CONCLUSION: Our results suggest the presence of high O&NS and low 
      antioxidant capacity accompanied with decreased levels of BDNF in PD patients, 
      especially those with EDS were deeper. These may represent the risk factors for 
      cellular injury and might reveal part of the mechanism causing the depressive 
      state in PD patients.
FAU - Eraldemir, Fatma Ceyla
AU  - Eraldemir FC
AD  - Department of Biochemistry, Kocaeli University School of Medicine , Kocaeli , 
      Turkey and.
FAU - Ozsoy, Doga
AU  - Ozsoy D
FAU - Bek, Sibel
AU  - Bek S
FAU - Kir, Hale
AU  - Kir H
FAU - Dervisoglu, Erkan
AU  - Dervisoglu E
LA  - eng
PT  - Journal Article
DEP - 20150217
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Depression/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*blood
MH  - *Oxidative Stress
MH  - Peritoneal Dialysis/*psychology
MH  - Young Adult
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - chronic kidney disease
OT  - nitrosative stress
OT  - oxidative stress
OT  - peritoneal dialysis
EDAT- 2015/02/18 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/02/18 06:00
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - 10.3109/0886022X.2015.1011551 [doi]
PST - ppublish
SO  - Ren Fail. 2015 May;37(4):722-6. doi: 10.3109/0886022X.2015.1011551. Epub 2015 Feb 
      17.