PMID- 25687836
OWN - NLM
STAT- MEDLINE
DCOM- 20160307
LR  - 20150613
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 41
IP  - 5
DP  - 2015 Aug
TI  - Randomized controlled trial of three burns dressings for partial thickness burns 
      in children.
PG  - 946-55
LID - S0305-4179(14)00376-3 [pii]
LID - 10.1016/j.burns.2014.11.005 [doi]
AB  - BACKGROUND: This study compared the effects of three silver dressing combinations 
      on small to medium size acute partial thickness burns in children, focusing on 
      re-epithelialization time, pain and distress during dressing changes. METHOD: 
      Children (0-15 years) with clean, </= 10% total body surface area (TBSA) partial 
      thickness burns who met the inclusion criteria were included in the study. 
      Children received either (1) Acticoat; (2) Acticoat with Mepitel; or (3) 
      Mepilex Ag dressings. Measures of burn re-epithelialization, pain, and distress 
      were recorded at dressing changes every 3-5 days until full re-epithelialization 
      occurred. RESULTS: One hundred and three children were recruited with 96 children 
      included for analysis. No infections were detected for the course of the study. 
      When adjusted for burn depth, Acticoat significantly increased the expected days 
      to full re-epithelialization by 40% (IRR = 1.40; 95% CI: 1.14-1.73, p < 0.01) and 
      Acticoat with Mepitel significantly increased the expected days to full 
      re-epithelialization by 33% (IRR = 1.33; 95% CI: 1.08-1.63, p </= 0.01) when 
      compared to Mepilex Ag. Expected FLACC scores in the Mepilex Ag group were 32% 
      lower at dressing removal (p = 0.01) and 37% lower at new dressing application (p 
      = 0.04); and scores in the Acticoat with Mepitel group were 23% lower at 
      dressing removal (p = 0.04) and 40% lower at new dressing application (p < 0.01), 
      in comparison to the Acticoat group. Expected Visual Analog Scale-Pain (VAS-P) 
      scores were 25% lower in the Mepilex Ag group at dressing removal (p = 0.04) and 
      34% lower in the Acticoat with Mepitel group (p = 0.02) at new dressing 
      application in comparison to the Acticoat group. There was no significant 
      difference between the Mepilex Ag and the Acticoat with Mepitel groups at all 
      timepoints and with any pain measure. CONCLUSION: Mepilex Ag is an effective 
      silver dressing, in terms of accelerated wound re-epithelialization time 
      (compared to Acticoat and Acticoat with Mepitel) and decreased pain during 
      dressing changes (compared to Acticoat), for clean, < 10% TBSA partial thickness 
      burns in children.
CI  - Copyright (c) 2014 Elsevier Ltd and ISBI. All rights reserved.
FAU - Gee Kee, E L
AU  - Gee Kee EL
AD  - Centre for Children's Burns and Trauma Research, Queensland Children's Medical 
      Research Institute, University of Queensland, Australia. Electronic address: 
      e.geekee@uq.edu.au.
FAU - Kimble, R M
AU  - Kimble RM
AD  - Centre for Children's Burns and Trauma Research, Queensland Children's Medical 
      Research Institute, University of Queensland, Australia; Stuart Pegg Paediatric 
      Burns Centre, Royal Children's Hospital, Brisbane, Australia.
FAU - Cuttle, L
AU  - Cuttle L
AD  - Centre for Children's Burns and Trauma Research, Queensland Children's Medical 
      Research Institute, University of Queensland, Australia; Tissue Repair and 
      Regeneration Program, Institute of Health and Biomedical Innovation, Queensland 
      University of Technology, Australia.
FAU - Khan, A
AU  - Khan A
AD  - School of Health and Rehabilitation Sciences, University of Queensland, 
      Australia.
FAU - Stockton, K A
AU  - Stockton KA
AD  - Centre for Children's Burns and Trauma Research, Queensland Children's Medical 
      Research Institute, University of Queensland, Australia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150214
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (Acticoat)
RN  - 0 (Polyesters)
RN  - 0 (Polyethylenes)
RN  - 0 (Silicones)
RN  - 0 (mepitel)
SB  - IM
MH  - Adolescent
MH  - Bandages
MH  - Burns/pathology/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - *Occlusive Dressings
MH  - Pain
MH  - Pain Measurement
MH  - Polyesters/*therapeutic use
MH  - Polyethylenes/*therapeutic use
MH  - *Re-Epithelialization
MH  - Regression Analysis
MH  - Silicones/*therapeutic use
MH  - Single-Blind Method
MH  - Time Factors
MH  - Treatment Outcome
MH  - Wound Healing
OTO - NOTNLM
OT  - Burn
OT  - Child
OT  - Pain
OT  - Partial thickness
OT  - Re-epithelialization
OT  - Silver dressing
EDAT- 2015/02/18 06:00
MHDA- 2016/03/08 06:00
CRDT- 2015/02/18 06:00
PHST- 2014/07/22 00:00 [received]
PHST- 2014/11/04 00:00 [revised]
PHST- 2014/11/05 00:00 [accepted]
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2016/03/08 06:00 [medline]
AID - S0305-4179(14)00376-3 [pii]
AID - 10.1016/j.burns.2014.11.005 [doi]
PST - ppublish
SO  - Burns. 2015 Aug;41(5):946-55. doi: 10.1016/j.burns.2014.11.005. Epub 2015 Feb 14.