PMID- 25687993
OWN - NLM
STAT- MEDLINE
DCOM- 20151203
LR  - 20181113
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 11
IP  - 4
DP  - 2015 Apr
TI  - Adenosine signalling in diabetes mellitus--pathophysiology and therapeutic 
      considerations.
PG  - 228-41
LID - 10.1038/nrendo.2015.10 [doi]
AB  - Adenosine is a key extracellular signalling molecule that regulates several 
      aspects of tissue function by activating four G-protein-coupled receptors, A1, 
      A2A, A2B and A1 adenosine receptors. Accumulating evidence highlights a critical 
      role for the adenosine system in the regulation of glucose homeostasis and the 
      pathophysiology of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus 
      (T2DM). Although adenosine signalling is known to affect insulin secretion, new 
      data indicate that adenosine signalling also contributes to the regulation of 
      beta-cell homeostasis and activity by controlling the proliferation and regeneration 
      of these cells as well as the survival of beta cells in inflammatory 
      microenvironments. Furthermore, adenosine is emerging as a major regulator of 
      insulin responsiveness by controlling insulin signalling in adipose tissue, 
      muscle and liver; adenosine also indirectly mediates effects on inflammatory 
      and/or immune cells in these tissues. This Review critically discusses the role 
      of the adenosine-adenosine receptor system in regulating both the onset and 
      progression of T1DM and T2DM, and the potential of pharmacological manipulation 
      of the adenosinergic system as an approach to manage T1DM, T2DM and their 
      associated complications.
FAU - Antonioli, Luca
AU  - Antonioli L
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 
      55, 56126 Pisa, Italy.
FAU - Blandizzi, Corrado
AU  - Blandizzi C
AD  - Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 
      55, 56126 Pisa, Italy.
FAU - Csoka, Balazs
AU  - Csoka B
AD  - Department of Surgery and Center for Immunity and Inflammation, Rutgers-New 
      Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 
      07103, USA.
FAU - Pacher, Pal
AU  - Pacher P
AD  - Section on Oxidative Stress Tissue Injury, Laboratories of Physiological Studies, 
      NIH/NIAAA, 5625 Fishers Lane, Bethesda, MD 20892, USA.
FAU - Hasko, Gyorgy
AU  - Hasko G
AD  - Department of Surgery and Center for Immunity and Inflammation, Rutgers-New 
      Jersey Medical School, 185 South Orange Avenue, University Heights, Newark, NJ 
      07103, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150217
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
RN  - 0 (Receptors, Purinergic P1)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/*metabolism
MH  - Animals
MH  - Diabetes Mellitus/*metabolism/physiopathology/therapy
MH  - Humans
MH  - Insulin Resistance
MH  - Receptors, Purinergic P1/*metabolism
MH  - *Signal Transduction
EDAT- 2015/02/18 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/18 06:00
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - nrendo.2015.10 [pii]
AID - 10.1038/nrendo.2015.10 [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2015 Apr;11(4):228-41. doi: 10.1038/nrendo.2015.10. Epub 2015 
      Feb 17.