PMID- 25688143
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20230203
IS  - 1941-3084 (Electronic)
IS  - 1941-3149 (Print)
IS  - 1941-3084 (Linking)
VI  - 8
IP  - 2
DP  - 2015 Apr
TI  - Safety of ventricular tachycardia ablation in clinical practice: findings from 
      9699 hospital discharge records.
PG  - 362-70
LID - 10.1161/CIRCEP.114.002336 [doi]
AB  - BACKGROUND: Outcomes of ventricular tachycardia (VT) ablation have been described 
      in clinical trials and single-center studies. We assessed the safety of VT 
      ablation in clinical practice. METHODS AND RESULTS: Using administrative 
      hospitalization data between 1994 and 2011, we identified hospitalizations with 
      primary diagnosis of VT (International Classification of Diseases-9 Clinical 
      Modification code: 427.1) and cardiac ablation (International Classification of 
      Diseases-9 Clinical Modification code: 37.34). We quantified in-hospital adverse 
      events (AEs), including death, stroke, intracerebral hemorrhage, pericardial 
      complications, hematoma or hemorrhage, blood transfusion, or cardiogenic shock. 
      Secondary outcomes included major AEs (stroke, tamponade, or death) and death. 
      Multivariable mixed effects models identified patient and hospital 
      characteristics associated with AEs. Of 9699 hospitalizations with VT ablations 
      (age, 56.5 +/- 17.6; 60.1% men), AEs were reported in 825 (8.5%), major AEs in 295 
      (3.0%), and death in 110 (1.1%). Heart failure had the strongest association with 
      death (odds ratio, 5.52; 95% confidence interval, 2.97-10.3) and major AE (odds 
      ratio, 2.99; 95% confidence interval, 2.15-4.16). Anemia (odds ratio, 4.84; 95% 
      confidence interval, 3.79-6.19) and unscheduled admission (odds ratio, 1.64; 95% 
      confidence interval, 1.37-1.97) were associated with AEs. During the study 
      period, incidence of AEs increased from 9.2% to 12.8% as did the burden of AE 
      risk factors (0.034 patient/y; P < 0.001). Hospital volume > 25 cases/y was 
      associated with fewer AEs compared with lower volume centers (6.4% versus 8.8%; P 
      = 0.008). CONCLUSIONS: VT ablation-associated AE rates in clinical practice are 
      similar to those reported in the literature. Over time rates have increased as 
      have the number of AE risk factors per patient. Ablations done electively and at 
      hospitals with higher procedural volume are associated with lower incidence of 
      AEs.
CI  - (c) 2015 American Heart Association, Inc.
FAU - Katz, David F
AU  - Katz DF
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.). David.Katz@UCDenver.edu.
FAU - Turakhia, Mintu P
AU  - Turakhia MP
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.).
FAU - Sauer, William H
AU  - Sauer WH
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.).
FAU - Tzou, Wendy S
AU  - Tzou WS
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.).
FAU - Heath, Russell R
AU  - Heath RR
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.).
FAU - Zipse, Matthew M
AU  - Zipse MM
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.).
FAU - Aleong, Ryan G
AU  - Aleong RG
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.).
FAU - Varosy, Paul D
AU  - Varosy PD
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.).
FAU - Kao, David P
AU  - Kao DP
AD  - From the University of Colorado, Aurora (D.F.K., W.H.S., W.S.T., M.M.Z., R.G.A., 
      P.D.V., D.P.K.); VA Palo Alto Health Care System, Stanford University, CA 
      (M.P.T.); University of Colorado Health, Fort Collins (R.R.H.); and Eastern 
      Colorado VA Medical Center, Denver (P.D.V.).
LA  - eng
GR  - L30 HL110124/HL/NHLBI NIH HHS/United States
GR  - T32 HL007822/HL/NHLBI NIH HHS/United States
GR  - 2 T32 HL007822-12/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150215
PL  - United States
TA  - Circ Arrhythm Electrophysiol
JT  - Circulation. Arrhythmia and electrophysiology
JID - 101474365
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Catheter Ablation/adverse effects/mortality
MH  - Databases, Factual
MH  - Elective Surgical Procedures
MH  - Female
MH  - Hospitals, High-Volume
MH  - Hospitals, Low-Volume
MH  - Humans
MH  - Incidence
MH  - International Classification of Diseases
MH  - Male
MH  - *Medical Records
MH  - Middle Aged
MH  - *Patient Discharge
MH  - Patient Safety
MH  - Postoperative Complications/mortality
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tachycardia, Ventricular/diagnosis/mortality/*surgery
MH  - Treatment Outcome
MH  - United States/epidemiology
MH  - Young Adult
PMC - PMC9893573
MID - NIHMS1613811
OTO - NOTNLM
OT  - catheter ablation
OT  - complication
OT  - tachycardia
COIS- Conflict of Interest Disclosures: William Sauer acknowledges receiving research 
      and educational support from Medtronic, St Jude, Boston Scientific and Biosense 
      Webster. All others have none.
EDAT- 2015/02/18 06:00
MHDA- 2015/06/26 06:00
PMCR- 2023/02/02
CRDT- 2015/02/18 06:00
PHST- 2014/08/25 00:00 [received]
PHST- 2015/02/03 00:00 [accepted]
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
PHST- 2023/02/02 00:00 [pmc-release]
AID - CIRCEP.114.002336 [pii]
AID - 10.1161/CIRCEP.114.002336 [doi]
PST - ppublish
SO  - Circ Arrhythm Electrophysiol. 2015 Apr;8(2):362-70. doi: 
      10.1161/CIRCEP.114.002336. Epub 2015 Feb 15.