PMID- 25688210
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150217
LR  - 20220223
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 6
DP  - 2015
TI  - Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen 
      presentation in dendritic cells.
PG  - 1
LID - 10.3389/fphys.2015.00001 [doi]
LID - 1
AB  - Dendritic cells (DCs) are outstanding antigen presenting cells (APCs) due to 
      their robust ability to internalize extracellular antigens using endocytic 
      processes such as receptor-mediated endocytosis, phagocytosis, and 
      macropinocytosis. Macropinocytosis mediates the non-specific uptake of soluble 
      antigens and occurs in DCs constitutively. Macropinocytosis plays a key role in 
      DC-mediated antigen presentation to T cells against pathogens and the efficiency 
      of macropinocytosis in antigen capture is regulated during the process of DC 
      maturation. Here, we review the methods to study macropinocytosis, describe our 
      current knowledge of the regulatory mechanisms of antigen uptake via 
      macropinocytosis and the intracellular trafficking route followed by 
      macropinocytosed antigens, and discuss the significance of macropinocytosis for 
      DC function.
FAU - Liu, Zhenzhen
AU  - Liu Z
AD  - Experimental Immunology Branch, National Cancer Institute, National Institutes of 
      Health Bethesda, MD, USA.
FAU - Roche, Paul A
AU  - Roche PA
AD  - Experimental Immunology Branch, National Cancer Institute, National Institutes of 
      Health Bethesda, MD, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150130
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC4311620
OTO - NOTNLM
OT  - MHC class II
OT  - antigen presentation
OT  - dendritic cell
OT  - endocytosis
OT  - macropinocytosis
EDAT- 2015/02/18 06:00
MHDA- 2015/02/18 06:01
PMCR- 2015/01/30
CRDT- 2015/02/18 06:00
PHST- 2014/11/11 00:00 [received]
PHST- 2015/01/05 00:00 [accepted]
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2015/02/18 06:01 [medline]
PHST- 2015/01/30 00:00 [pmc-release]
AID - 10.3389/fphys.2015.00001 [doi]
PST - epublish
SO  - Front Physiol. 2015 Jan 30;6:1. doi: 10.3389/fphys.2015.00001. eCollection 2015.