PMID- 25688539
OWN - NLM
STAT- MEDLINE
DCOM- 20151229
LR  - 20181113
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 41
IP  - 7
DP  - 2015 Apr
TI  - Spatio-temporal dynamics of adaptation in the human visual system: a high-density 
      electrical mapping study.
PG  - 925-39
LID - 10.1111/ejn.12849 [doi]
AB  - When sensory inputs are presented serially, response amplitudes to stimulus 
      repetitions generally decrease as a function of presentation rate, diminishing 
      rapidly as inter-stimulus intervals (ISIs) fall below 1 s. This 'adaptation' is 
      believed to represent mechanisms by which sensory systems reduce responsivity to 
      consistent environmental inputs, freeing resources to respond to potentially more 
      relevant inputs. While auditory adaptation functions have been relatively well 
      characterized, considerably less is known about visual adaptation in humans. 
      Here, high-density visual-evoked potentials (VEPs) were recorded while two 
      paradigms were used to interrogate visual adaptation. The first presented 
      stimulus pairs with varying ISIs, comparing VEP amplitude to the second stimulus 
      with that of the first (paired-presentation). The second involved blocks of 
      stimulation (N = 100) at various ISIs and comparison of VEP amplitude between 
      blocks of differing ISIs (block-presentation). Robust VEP modulations were 
      evident as a function of presentation rate in the block-paradigm, with strongest 
      modulations in the 130-150 ms and 160-180 ms visual processing phases. In 
      paired-presentations, with ISIs of just 200-300 ms, an enhancement of VEP was 
      evident when comparing S2 with S1, with no significant effect of presentation 
      rate. Importantly, in block-presentations, adaptation effects were statistically 
      robust at the individual participant level. These data suggest that a more taxing 
      block-presentation paradigm is better suited to engage visual adaptation 
      mechanisms than a paired-presentation design. The increased sensitivity of the 
      visual processing metric obtained in the block-paradigm has implications for the 
      examination of visual processing deficits in clinical populations.
CI  - (c) 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Andrade, Gizely N
AU  - Andrade GN
AD  - Departments of Pediatrics and Neuroscience, The Sheryl and Daniel R. Tishman 
      Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation 
      Center (CERC), Albert Einstein College of Medicine, Van Etten Building - Wing 1C, 
      1225 Morris Park Avenue, Bronx, NY, 10461, USA; Departments of Psychology & 
      Biology, The Graduate Center of the City University of New York, New York, NY, 
      USA.
FAU - Butler, John S
AU  - Butler JS
FAU - Mercier, Manuel R
AU  - Mercier MR
FAU - Molholm, Sophie
AU  - Molholm S
FAU - Foxe, John J
AU  - Foxe JJ
LA  - eng
GR  - R01 - MH085322/MH/NIMH NIH HHS/United States
GR  - R01 MH085322/MH/NIMH NIH HHS/United States
GR  - NICHD P30 HD071593/PHS HHS/United States
GR  - UL1 TR001073/TR/NCATS NIH HHS/United States
GR  - P30 HD071593/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150216
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Adaptation, Physiological/*physiology
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping
MH  - Evoked Potentials, Visual/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Photic Stimulation
MH  - Time Factors
MH  - Visual Pathways/*physiology
MH  - Visual Perception/*physiology
PMC - PMC4390449
MID - NIHMS654849
OTO - NOTNLM
OT  - EEG
OT  - habituation
OT  - inhibition
OT  - plasticity
OT  - vision
COIS- Conflict of Interest Statement All authors of this paper declare no 
      conflicts-of-interest, financial or otherwise, that could have biased their 
      contributions to this work. The senior author, Dr. Foxe, attests that all authors 
      had access to the full dataset and to all stages of the analyses.
EDAT- 2015/02/18 06:00
MHDA- 2015/12/30 06:00
PMCR- 2016/04/01
CRDT- 2015/02/18 06:00
PHST- 2014/09/18 00:00 [received]
PHST- 2014/12/31 00:00 [accepted]
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2015/12/30 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.1111/ejn.12849 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2015 Apr;41(7):925-39. doi: 10.1111/ejn.12849. Epub 2015 Feb 16.