PMID- 25688974
OWN - NLM
STAT- MEDLINE
DCOM- 20151229
LR  - 20201217
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 2
DP  - 2015
TI  - Lrp4 domains differentially regulate limb/brain development and synaptic 
      plasticity.
PG  - e0116701
LID - 10.1371/journal.pone.0116701 [doi]
LID - e0116701
AB  - Apolipoprotein E (ApoE) genotype is the strongest predictor of Alzheimer's 
      Disease (AD) risk. ApoE is a cholesterol transport protein that binds to members 
      of the Low-Density Lipoprotein (LDL) Receptor family, which includes LDL Receptor 
      Related Protein 4 (Lrp4). Lrp4, together with one of its ligands Agrin and its 
      co-receptors Muscle Specific Kinase (MuSK) and Amyloid Precursor Protein (APP), 
      regulates neuromuscular junction (NMJ) formation. All four proteins are also 
      expressed in the adult brain, and APP, MuSK, and Agrin are required for normal 
      synapse function in the CNS. Here, we show that Lrp4 is also required for normal 
      hippocampal plasticity. In contrast to the closely related Lrp8/Apoer2, the 
      intracellular domain of Lrp4 does not appear to be necessary for normal 
      expression and maintenance of long-term potentiation at central synapses or for 
      the formation and maintenance of peripheral NMJs. However, it does play a role in 
      limb development.
FAU - Pohlkamp, Theresa
AU  - Pohlkamp T
AD  - Department of Molecular Genetics, University of Texas Southwestern Medical 
      Center, Dallas, Texas, 75390, United States of America; Center for Translational 
      Neurodegeneration Research, University of Texas Southwestern Medical Center, 
      Dallas, Texas, 75390, United States of America.
FAU - Durakoglugil, Murat
AU  - Durakoglugil M
AD  - Department of Molecular Genetics, University of Texas Southwestern Medical 
      Center, Dallas, Texas, 75390, United States of America; Center for Translational 
      Neurodegeneration Research, University of Texas Southwestern Medical Center, 
      Dallas, Texas, 75390, United States of America.
FAU - Lane-Donovan, Courtney
AU  - Lane-Donovan C
AD  - Department of Molecular Genetics, University of Texas Southwestern Medical 
      Center, Dallas, Texas, 75390, United States of America; Center for Translational 
      Neurodegeneration Research, University of Texas Southwestern Medical Center, 
      Dallas, Texas, 75390, United States of America.
FAU - Xian, Xunde
AU  - Xian X
AD  - Department of Molecular Genetics, University of Texas Southwestern Medical 
      Center, Dallas, Texas, 75390, United States of America; Center for Translational 
      Neurodegeneration Research, University of Texas Southwestern Medical Center, 
      Dallas, Texas, 75390, United States of America.
FAU - Johnson, Eric B
AU  - Johnson EB
AD  - Department of Molecular Genetics, University of Texas Southwestern Medical 
      Center, Dallas, Texas, 75390, United States of America.
FAU - Hammer, Robert E
AU  - Hammer RE
AD  - Department of Biochemistry, University of Texas Southwestern Medical Center, 
      Dallas, Texas, 75390, United States of America.
FAU - Herz, Joachim
AU  - Herz J
AD  - Department of Molecular Genetics, University of Texas Southwestern Medical 
      Center, Dallas, Texas, 75390, United States of America; Department of 
      Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, 
      75390, United States of America; Department of Neurology and Neurotherapeutics, 
      University of Texas Southwestern Medical Center, Dallas, Texas, 75390, United 
      States of America; Center for Translational Neurodegeneration Research, 
      University of Texas Southwestern Medical Center, Dallas, Texas, 75390, United 
      States of America.
LA  - eng
GR  - F30 AG047799/AG/NIA NIH HHS/United States
GR  - R01 HL063762/HL/NHLBI NIH HHS/United States
GR  - R37 HL063762/HL/NHLBI NIH HHS/United States
GR  - R37 HL63762/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150217
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (LDL-Receptor Related Proteins)
RN  - 0 (LRP4 protein, human)
SB  - IM
MH  - Animals
MH  - Brain/*embryology
MH  - Extremities/*embryology
MH  - Humans
MH  - LDL-Receptor Related Proteins/chemistry/*genetics
MH  - Limb Deformities, Congenital/genetics
MH  - Long-Term Potentiation/genetics
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Mutation
MH  - Neuronal Plasticity/*genetics
MH  - Organogenesis/*genetics
MH  - Phenotype
MH  - Protein Interaction Domains and Motifs/*genetics
PMC - PMC4331535
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/02/18 06:00
MHDA- 2015/12/30 06:00
PMCR- 2015/02/17
CRDT- 2015/02/18 06:00
PHST- 2014/10/16 00:00 [received]
PHST- 2014/12/14 00:00 [accepted]
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2015/12/30 06:00 [medline]
PHST- 2015/02/17 00:00 [pmc-release]
AID - PONE-D-14-46177 [pii]
AID - 10.1371/journal.pone.0116701 [doi]
PST - epublish
SO  - PLoS One. 2015 Feb 17;10(2):e0116701. doi: 10.1371/journal.pone.0116701. 
      eCollection 2015.