PMID- 25689130
OWN - NLM
STAT- MEDLINE
DCOM- 20160607
LR  - 20150903
IS  - 1365-2885 (Electronic)
IS  - 0140-7783 (Linking)
VI  - 38
IP  - 5
DP  - 2015 Oct
TI  - Impact of an experimental PRRSV and Streptococcus suis coinfection on the 
      pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in 
      pigs.
PG  - 475-81
LID - 10.1111/jvp.12209 [doi]
AB  - This study determined the impact of porcine reproductive and respiratory syndrome 
      virus (PRRSV) and Streptococcus suis coinfection on the pharmacokinetic (PK) 
      profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. 
      Eighteen clinically normal crossbred gilts were assigned by weight into a 
      challenge group (10 pigs) and control group (eight pigs). Pigs in both groups 
      received a single i.m. injection of ceftiofur hydrochloride (Excenel RTU Sterile 
      Suspension; Zoetis) at a 5 mg/kg BW dose. Serial blood samples were collected to 
      characterize the plasma concentration curve. After a 10 days drug washout period, 
      the challenge group was inoculated with 2 mL of PRRSV isolate VR-2385 (10(5.75) 
      50% tissue culture infective doses per mL) intranasally and 8 days later 
      inoculated S. suis. When clinical disease was evident, the second PK assessment 
      began in both challenge and control groups. Coinfected pigs demonstrated lower 
      values of AUC and CMAX , but higher values of Cl/F and Vz/F indicating drug 
      kinetics were altered by infection. The data from this study have implications on 
      ceftiofur treatment regimens in diseased pigs.
CI  - (c) 2015 John Wiley & Sons Ltd.
FAU - Day, D N
AU  - Day DN
AD  - Swine Medicine Education Center, College of Veterinary Medicine, Iowa State 
      University, Ames, IA, USA.
FAU - Sparks, J W
AU  - Sparks JW
AD  - Swine Medicine Education Center, College of Veterinary Medicine, Iowa State 
      University, Ames, IA, USA.
FAU - Karriker, L A
AU  - Karriker LA
AD  - Swine Medicine Education Center, College of Veterinary Medicine, Iowa State 
      University, Ames, IA, USA.
FAU - Stalder, K J
AU  - Stalder KJ
AD  - Department of Animal Science, Iowa State University, Ames, IA, USA.
FAU - Wulf, L W
AU  - Wulf LW
AD  - Pharmacology Analytical Support Team (PhAST), College of Veterinary Medicine, 
      Iowa State University, Ames, IA, USA.
FAU - Zhang, J
AU  - Zhang J
AD  - Veterinary Diagnostic and Production Animal Medicine, College of Veterinary 
      Medicine, Iowa State University, Ames, IA, USA.
FAU - Kinyon, J M
AU  - Kinyon JM
AD  - Veterinary Diagnostic and Production Animal Medicine, College of Veterinary 
      Medicine, Iowa State University, Ames, IA, USA.
FAU - Stock, M L
AU  - Stock ML
AD  - Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, 
      IA, USA.
FAU - Gehring, R
AU  - Gehring R
AD  - Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State 
      University, Manhattan, KS, USA.
FAU - Wang, C
AU  - Wang C
AD  - Veterinary Diagnostic and Production Animal Medicine, College of Veterinary 
      Medicine, Iowa State University, Ames, IA, USA.
FAU - Ellingson, J
AU  - Ellingson J
AD  - Swine Medicine Education Center, College of Veterinary Medicine, Iowa State 
      University, Ames, IA, USA.
FAU - Coetzee, J F
AU  - Coetzee JF
AD  - Pharmacology Analytical Support Team (PhAST), College of Veterinary Medicine, 
      Iowa State University, Ames, IA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150216
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cephalosporins)
RN  - 83JL932I1C (ceftiofur)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacokinetics/therapeutic use
MH  - Cephalosporins/*pharmacokinetics/therapeutic use
MH  - Coinfection/drug therapy/metabolism/microbiology/*veterinary/virology
MH  - Female
MH  - Injections, Intramuscular/veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/*drug 
      therapy/metabolism/microbiology
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Streptococcal Infections/complications/drug 
      therapy/microbiology/*veterinary/virology
MH  - *Streptococcus suis
MH  - Swine/metabolism/microbiology/virology
MH  - Swine Diseases/*drug therapy/microbiology/virology
EDAT- 2015/02/18 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/02/18 06:00
PHST- 2014/09/22 00:00 [received]
PHST- 2015/01/16 00:00 [accepted]
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 10.1111/jvp.12209 [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 2015 Oct;38(5):475-81. doi: 10.1111/jvp.12209. Epub 2015 
      Feb 16.