PMID- 25689396
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20221207
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 32
IP  - 1
DP  - 2016 Jan
TI  - Effects of tea or tea extract on metabolic profiles in patients with type 2 
      diabetes mellitus: a meta-analysis of ten randomized controlled trials.
PG  - 2-10
LID - 10.1002/dmrr.2641 [doi]
AB  - As consumption of tea has been confirmed as a protective factor for type 2 
      diabetes mellitus (T2DM), it would be interesting to know if T2DM patients could 
      benefit from tea. Because of small sample sizes and inconsistent results of 
      previous studies, we performed this meta-analysis to reevaluate the effects of 
      tea or tea extract on all available outcomes in patients with T2DM. We 
      systematically searched electronic databases of PubMed, Cochrane Library and 
      EMBASE to identify randomized controlled trials of tea in T2DM patients up to 
      January 2015. Weight mean differences for the changes in all outcomes were pooled 
      by Review Manager 5.2 (Cochrane Collaboration, Oxford, England). A total of ten 
      trials including 608 subjects were identified. The meta-analysis found that tea 
      could alleviate the decrease of fasting blood insulin [1.30 U/L, 95% CI (0.36, 
      2.24)], and reduced waist circumference only in more than 8-week intervention 
      [-2.70 cm, 95% CI (-4.72, -0.69)], whereas there were no statistically 
      significant differences with regard to homeostasis model of insulin resistance 
      0.38 (-0.18, 0.95), fasting blood glucose -0.05 mmol/L (-0.51, 0.40), low density 
      lipoprotein-cholesterol 0.07 mmol/L (-0.15, 0.29), high density 
      lipoprotein-cholesterol 0.01 mmol/L (-0.08, 0.09), body mass index -0.15 kg/m(2) 
      (-0.50, 0.21), SBP 0.35 mmHg (-3.54, 4.24), DBP -1.02 mmHg (-3.53, 1.48), 
      triglycerides -0.11 mmol/L (-0.28, 0.05) and fasting cholesterol -0.05 mmol/L 
      (-0.20, 0.11) in patients with T2DM, and leptin, ADPN, CRE and UA were also 
      non-significant. The intervention of tea or tea extraction could maintain a 
      stable fasting blood insulin and reduce waist circumference in the T2DM patients; 
      however, the effects on other outcomes were not significant. Copyright (c) 2015 
      John Wiley & Sons, Ltd.
CI  - Copyright (c) 2015 John Wiley & Sons, Ltd.
FAU - Li, Yanchuan
AU  - Li Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical 
      University, Harbin, China.
AD  - National Key Discipline, School of Public Health, Harbin Medical University, 
      Harbin, China.
FAU - Wang, Cheng
AU  - Wang C
AD  - National Key Discipline, School of Public Health, Harbin Medical University, 
      Harbin, China.
AD  - Department of Environmental Hygiene, School of Public Health, Harbin Medical 
      University, Harbin, China.
FAU - Huai, Qingjie
AU  - Huai Q
AD  - Department of Virus, Harbin Center for Disease Control and Prevention, Harbin, 
      China.
FAU - Guo, Fuchuan
AU  - Guo F
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical 
      University, Harbin, China.
AD  - National Key Discipline, School of Public Health, Harbin Medical University, 
      Harbin, China.
FAU - Liu, Liyan
AU  - Liu L
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical 
      University, Harbin, China.
AD  - National Key Discipline, School of Public Health, Harbin Medical University, 
      Harbin, China.
FAU - Feng, Rennan
AU  - Feng R
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical 
      University, Harbin, China.
AD  - National Key Discipline, School of Public Health, Harbin Medical University, 
      Harbin, China.
FAU - Sun, Changhao
AU  - Sun C
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical 
      University, Harbin, China.
AD  - National Key Discipline, School of Public Health, Harbin Medical University, 
      Harbin, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150421
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Appetite Depressants)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (Tea)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Appetite Depressants/therapeutic use
MH  - *Appetite Regulation
MH  - Camellia sinensis/*chemistry
MH  - Diabetes Mellitus, Type 2/blood/complications/*diet therapy/metabolism
MH  - Diet, Diabetic
MH  - Diet, Reducing
MH  - *Dietary Supplements
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hyperglycemia/prevention & control
MH  - Hyperlipidemias/complications/prevention & control
MH  - Hypoglycemic Agents/therapeutic use
MH  - Insulin Resistance
MH  - Overweight/blood/complications/*diet therapy/metabolism
MH  - Plant Extracts/*therapeutic use
MH  - Plant Leaves/chemistry
MH  - Randomized Controlled Trials as Topic
MH  - *Tea
MH  - Waist Circumference
MH  - Weight Loss
OTO - NOTNLM
OT  - T2DM
OT  - meta-analysis
OT  - metabolic profile
OT  - tea
EDAT- 2015/02/18 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/02/18 06:00
PHST- 2014/08/20 00:00 [received]
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/02/18 06:00 [entrez]
PHST- 2015/02/18 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - 10.1002/dmrr.2641 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2016 Jan;32(1):2-10. doi: 10.1002/dmrr.2641. Epub 2015 
      Apr 21.