PMID- 25690530
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20190108
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 18
IP  - 1
DP  - 2015
TI  - Active and latent tuberculosis among HIV-positive injecting drug users in 
      Indonesia.
PG  - 19317
LID - 10.7448/IAS.18.1.19317 [doi]
LID - 19317 [doi]
AB  - INTRODUCTION: Injecting drug use (IDU) is associated with tuberculosis but few 
      data are available from low-income settings. We examined IDU in relation to 
      active and latent tuberculosis (LTBI) among HIV-positive individuals in 
      Indonesia, which has a high burden of tuberculosis and a rapidly growing HIV 
      epidemic strongly driven by IDU. METHODS: Active tuberculosis was measured 
      prospectively among 1900 consecutive antiretroviral treatment (ART)-naive adult 
      patients entering care in a clinic in West Java. Prevalence of LTBI was 
      determined cross-sectionally in a subset of 518 ART-experienced patients using an 
      interferon-gamma release assay. RESULTS: Patients with a history of IDU (53.1%) 
      more often reported a history of tuberculosis treatment (34.8% vs. 21.9%, p < 
      0.001), more often received tuberculosis treatment during follow-up (adjusted HR 
      = 1.71; 95% CI: 1.25-2.35) and more often had bacteriologically confirmed 
      tuberculosis (OR = 1.67; 95% CI: 0.94-2.96). LTBI was equally prevalent among 
      people with and without a history of IDU (29.1 vs. 30.4%, NS). The risk estimates 
      did not change after adjustment for CD4 cell count or ART. CONCLUSIONS: 
      HIV-positive individuals with a history of IDU in Indonesia have more active 
      tuberculosis, with similar rates of LTBI. Within the HIV clinic, LTBI screening 
      and isoniazid preventive therapy may be prioritized to patients with a history of 
      IDU.
FAU - Meijerink, Hinta
AU  - Meijerink H
AD  - Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The 
      Netherlands.
FAU - Wisaksana, Rudi
AU  - Wisaksana R
AD  - Health Research Unit, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin 
      Hospital, Bandung, Indonesia.
AD  - Department of Internal Medicine, Faculty of Medicine, Hasan Sadikin Hospital, 
      Padjadjaran University, Bandung, Indonesia.
FAU - Lestari, Mery
AU  - Lestari M
AD  - Department of Internal Medicine, Faculty of Medicine, Hasan Sadikin Hospital, 
      Padjadjaran University, Bandung, Indonesia.
FAU - Meilana, Intan
AU  - Meilana I
AD  - Department of Internal Medicine, Faculty of Medicine, Hasan Sadikin Hospital, 
      Padjadjaran University, Bandung, Indonesia.
FAU - Chaidir, Lydia
AU  - Chaidir L
AD  - Health Research Unit, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin 
      Hospital, Bandung, Indonesia.
FAU - van der Ven, Andre J A M
AU  - van der Ven AJ
AD  - Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The 
      Netherlands.
FAU - Alisjahbana, Bachti
AU  - Alisjahbana B
AD  - Health Research Unit, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin 
      Hospital, Bandung, Indonesia.
FAU - van Crevel, Reinout
AU  - van Crevel R
AD  - Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The 
      Netherlands; Reinout.vanCrevel@radboudumc.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150216
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
SB  - IM
MH  - Adult
MH  - Female
MH  - HIV Infections/*complications
MH  - Humans
MH  - Indonesia/epidemiology
MH  - Latent Tuberculosis/epidemiology
MH  - Male
MH  - Substance Abuse, Intravenous/*complications
MH  - Tuberculosis/*epidemiology
PMC - PMC4331401
OTO - NOTNLM
OT  - Mycobacterium tuberculosis
OT  - cohort studies
OT  - human immunodeficiency virus
OT  - intravenous
OT  - latent tuberculosis infection
OT  - substance abuse
EDAT- 2015/02/19 06:00
MHDA- 2016/05/18 06:00
PMCR- 2015/02/16
CRDT- 2015/02/19 06:00
PHST- 2014/06/20 00:00 [received]
PHST- 2014/11/19 00:00 [revised]
PHST- 2015/01/13 00:00 [accepted]
PHST- 2015/02/19 06:00 [entrez]
PHST- 2015/02/19 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
PHST- 2015/02/16 00:00 [pmc-release]
AID - 19317 [pii]
AID - 10.7448/IAS.18.1.19317 [doi]
PST - epublish
SO  - J Int AIDS Soc. 2015 Feb 16;18(1):19317. doi: 10.7448/IAS.18.1.19317. eCollection 
      2015.