PMID- 25690707
OWN - NLM
STAT- MEDLINE
DCOM- 20150730
LR  - 20200306
IS  - 1420-9071 (Electronic)
IS  - 1420-682X (Linking)
VI  - 72
IP  - 12
DP  - 2015 Jun
TI  - Role of Rab GTPases and their interacting proteins in mediating metabolic 
      signalling and regulation.
PG  - 2289-304
LID - 10.1007/s00018-015-1862-x [doi]
AB  - The vesicular transport pathways, which shuttle materials to and from the cell 
      surface and within the cell, and the metabolic (growth factor and nutrient) 
      signalling pathways, which integrate a variety of extracellular and intracellular 
      signals to mediate growth, proliferation or survival, are both important for 
      cellular physiology. There is evidence to suggest that the transport and 
      metabolic signalling pathways intersect-vesicular transport can affect the 
      regulation of metabolic signals and vice versa. The Rab family GTPases regulate 
      the specificity of vesicular transport steps in the cell. Together with their 
      interacting proteins, Rabs would likely constitute the points of intersection 
      between vesicular transport and metabolic signalling pathways. Examples of these 
      points would include growth factor signalling, glucose and lipid metabolism, as 
      well as autophagy. Many of these processes involve mechanistic/mammalian target 
      of rapamycin (mTOR) complex 1 (mTORC1) in downstream cascades, or are regulated 
      by TORC signalling. A general functionality of the vesicular transport processes 
      controlled by the Rabs is also important for spatial and temporal regulation of 
      the transmission of metabolic signals between the cell surface and the nucleus. 
      In other cases, specific Rabs and their interacting proteins are known to 
      function in recruiting metabolism-related proteins to target membranes, or may 
      compete with other factors in the TORC signalling pathway as a means of metabolic 
      regulation. We review and discuss herein examples of how Rabs and their 
      interacting proteins can mediate metabolic signalling and regulation in cells.
FAU - Chua, Christelle En Lin
AU  - Chua CE
AD  - Department of Biochemistry, Yong Loo Lin School of Medicine, National University 
      Health System, 8 Medical Drive, Singapore, 117597, Singapore, g0901904@u.nus.edu.
FAU - Tang, Bor Luen
AU  - Tang BL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150219
PL  - Switzerland
TA  - Cell Mol Life Sci
JT  - Cellular and molecular life sciences : CMLS
JID - 9705402
RN  - EC 3.6.5.2 (rab GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - *Cell Physiological Phenomena
MH  - Humans
MH  - Models, Biological
MH  - *Protein Interaction Maps
MH  - *Signal Transduction
MH  - rab GTP-Binding Proteins/*metabolism
EDAT- 2015/02/19 06:00
MHDA- 2015/08/01 06:00
CRDT- 2015/02/19 06:00
PHST- 2014/12/15 00:00 [received]
PHST- 2015/02/11 00:00 [accepted]
PHST- 2015/02/09 00:00 [revised]
PHST- 2015/02/19 06:00 [entrez]
PHST- 2015/02/19 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
AID - 10.1007/s00018-015-1862-x [doi]
PST - ppublish
SO  - Cell Mol Life Sci. 2015 Jun;72(12):2289-304. doi: 10.1007/s00018-015-1862-x. Epub 
      2015 Feb 19.