PMID- 25691534
OWN - NLM
STAT- MEDLINE
DCOM- 20190918
LR  - 20190918
IS  - 1557-1246 (Electronic)
IS  - 1087-0547 (Linking)
VI  - 22
IP  - 9
DP  - 2018 Jul
TI  - BDNF 196 G/A and COMT Val158Met Polymorphisms and Susceptibility to ADHD: A 
      Meta-Analysis.
PG  - 872-877
LID - 10.1177/1087054715570389 [doi]
AB  - OBJECTIVE: The aim of this study was to determine whether the brain-derived 
      neurotrophic factor ( BDNF) 196 G/A or catechol- O-methyltransferase ( COMT) 
      Val158Met polymorphisms is associated with susceptibility to ADHD. METHOD: We 
      conducted a meta-analysis of the associations between the BDNF 196 G/A and COMT 
      Val158Met polymorphisms and ADHD. RESULTS: Sixteen studies consisting of 3,594 
      patients with ADHD and 4,040 controls were included in this meta-analysis. Our 
      results showed no association between ADHD and the BDNF 196A allele in all 
      participants (odds ratio [OR] = 0.958, 95% confidence interval [CI] = [0.800, 
      1.146], p = .638), European or Asian population. Meta-analysis indicated no 
      association between ADHD and the COMT G allele in all study participants (OR = 
      1.078, 95% CI = [0.962, 1.207], p = .196), European or Asian population. 
      CONCLUSION: This meta-analysis showed a lack of association between the BDNF 196 
      G/A and COMT Val158Met polymorphisms and ADHD.
FAU - Lee, Young Ho
AU  - Lee YH
AD  - 1 Korea University College of Medicine, Seoul, Korea.
FAU - Song, Gwan Gyu
AU  - Song GG
AD  - 1 Korea University College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20150217
PL  - United States
TA  - J Atten Disord
JT  - Journal of attention disorders
JID - 9615686
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.1.1.6 (COMT protein, human)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Attention Deficit Disorder with Hyperactivity/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - ADHD
OT  - BDNF
OT  - COMT
OT  - meta-analysis
OT  - polymorphism
EDAT- 2015/02/19 06:00
MHDA- 2019/09/19 06:00
CRDT- 2015/02/19 06:00
PHST- 2015/02/19 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
PHST- 2015/02/19 06:00 [entrez]
AID - 1087054715570389 [pii]
AID - 10.1177/1087054715570389 [doi]
PST - ppublish
SO  - J Atten Disord. 2018 Jul;22(9):872-877. doi: 10.1177/1087054715570389. Epub 2015 
      Feb 17.