PMID- 25692400
OWN - NLM
STAT- MEDLINE
DCOM- 20160127
LR  - 20201209
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 18
IP  - 5
DP  - 2015 May
TI  - Protective Effects of Quercetin Against HgCl(2)-Induced Nephrotoxicity in 
      Sprague-Dawley Rats.
PG  - 524-34
LID - 10.1089/jmf.2014.3242 [doi]
AB  - Mercury is a well-known environmental pollutant that can cause nephropathic 
      diseases, including acute kidney injury (AKI). Although quercetin (QC), a natural 
      flavonoid, has been reported to have medicinal properties, its potential 
      protective effects against mercury-induced AKI have not been evaluated. In this 
      study, the protective effect of QC against mercury-induced AKI was investigated 
      using biochemical parameters, new protein-based urinary biomarkers, and a 
      histopathological approach. A 250 mg/kg dose of QC was administered orally to 
      Sprague-Dawley male rats for 3 days before administration of mercury chloride 
      (HgCl2). All animals were sacrificed at 24 h after HgCl2 treatment, and 
      biomarkers associated with nephrotoxicity were measured. Our data showed that QC 
      absolutely prevented HgCl2-induced AKI, as indicated by biochemical parameters 
      such as blood urea nitrogen (BUN) and serum creatinine (sCr). In particular, QC 
      markedly decreased the accumulation of Hg in the kidney. Urinary excretion of 
      protein-based biomarkers, including clusterin, kidney injury molecule-1 (KIM-1), 
      neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant 
      protein-1 (MCP-1), tissue inhibitor of metalloproteinases 1 (TIMP-1), and 
      vascular endothelial growth factor (VEGF) in response to HgCl2 administration 
      were significantly decreased by QC pretreatment relative to that in the 
      HgCl2-treated group. Furthermore, urinary excretion of metallothionein and Hg 
      were significantly elevated by QC pretreatment. Histopathological examination 
      indicated that QC protected against HgCl2-induced proximal tubular damage in the 
      kidney. A TUNEL assay indicated that QC pretreatment significantly reduced 
      apoptotic cell death in the kidney. The administration of QC provided significant 
      protective effects against mercury-induced AKI.
FAU - Shin, Yu Jin
AU  - Shin YJ
AD  - 1 College of Pharmacy, Pusan National University , Busan, South Korea .
FAU - Kim, Jeong Jun
AU  - Kim JJ
FAU - Kim, Ye Ji
AU  - Kim YJ
FAU - Kim, Won Hee
AU  - Kim WH
FAU - Park, Eun Young
AU  - Park EY
FAU - Kim, In Young
AU  - Kim IY
FAU - Shin, Han-Seung
AU  - Shin HS
FAU - Kim, Kyeong Seok
AU  - Kim KS
FAU - Lee, Eui-Kyung
AU  - Lee EK
FAU - Chung, Kyu Hyuck
AU  - Chung KH
FAU - Lee, Byung Mu
AU  - Lee BM
FAU - Kim, Hyung Sik
AU  - Kim HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150218
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Havcr1protein, rat)
RN  - 0 (Lcn2 protein, rat)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Protective Agents)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 53GH7MZT1R (Mercuric Chloride)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - Acute Kidney Injury/chemically induced/*drug therapy/genetics/metabolism
MH  - Acute-Phase Proteins/genetics/metabolism
MH  - Animals
MH  - Cell Adhesion Molecules/genetics/metabolism
MH  - Humans
MH  - Kidney/drug effects/metabolism
MH  - Lipocalin-2
MH  - Lipocalins/genetics/metabolism
MH  - Male
MH  - Mercuric Chloride/metabolism/*toxicity
MH  - Protective Agents/*administration & dosage
MH  - Proto-Oncogene Proteins/genetics/metabolism
MH  - Quercetin/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vascular Endothelial Growth Factor A/genetics/metabolism
OTO - NOTNLM
OT  - acute kidney injury
OT  - mercury
OT  - metallothionein
OT  - protective effect
OT  - quercetin
EDAT- 2015/02/19 06:00
MHDA- 2016/01/28 06:00
CRDT- 2015/02/19 06:00
PHST- 2015/02/19 06:00 [entrez]
PHST- 2015/02/19 06:00 [pubmed]
PHST- 2016/01/28 06:00 [medline]
AID - 10.1089/jmf.2014.3242 [doi]
PST - ppublish
SO  - J Med Food. 2015 May;18(5):524-34. doi: 10.1089/jmf.2014.3242. Epub 2015 Feb 18.