PMID- 25694284
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20150219
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 142
IP  - 11
DP  - 2014 Nov
TI  - [Correlation between aPTT and antifactor Xa to determine therapeutic ranges for 
      unfractionated heparin].
PG  - 1392-7
LID - S0034-98872014001100005 [pii]
LID - 10.4067/S0034-98872014001100005 [doi]
AB  - BACKGROUND: The therapeutic range (TR) of activated partial thromboplastin time 
      (aPTT) for unfractionated heparin (UFH) dosing was established in the 1970 
      decade. Since then aPTT determination has changed. Current TR may be sub or 
      supra-therapeutic depending on the reagents of the test, and therefore, 
      responsible for complications of therapy. AIM: To establish the TR for UFH dosing 
      in our institution using antifactor Xa analysis as reference standard. MATERIAL 
      AND METHODS: After obtaining an informed consent, 43 blood samples were obtained 
      for aPTT determination and antifactor Xa assay in 23 patients treated with 
      intravenous UFH. Samples were processed at Emergency and Hemostasis Labs. We 
      excluded patients receiving other anticoagulants, with thrombophilia, pregnancy 
      or liver disease. RESULTS: Mean aPTT values in the Hemostasis and Emergency labs 
      ​​were 57.1 +/- 18.9 and 56.6 +/- 18.3 seconds, respectively (p = 0.77). The squared 
      correlation coefficients between aPTT and antifactor Xa at hemostasis and 
      emergency labs were R2 0.5 and 0.45 respectively, p < 0.001. Using a linear 
      regression analysis, therapeutic aPTT range values ​​in our laboratory were 
      established between 50 and 80 seconds, corresponding to antifactor Xa values of 
      0.3 to 0.7 IU/mL. CONCLUSIONS: According to current recommendations, validation 
      of aPTT determination with reference techniques should be done in every 
      institution.
FAU - Marine, Leopoldo
AU  - Marine L
FAU - Sanchez, Gonzalo
AU  - Sanchez G
FAU - Vargas, Jose Francisco
AU  - Vargas JF
FAU - Zuniga, Pamela
AU  - Zuniga P
FAU - Aizman, Andres
AU  - Aizman A
FAU - Mertens, Renato
AU  - Mertens R
FAU - Bergoeing, Michel
AU  - Bergoeing M
FAU - Munoz, Blanca
AU  - Munoz B
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Correlacion de valores de TTPa con anti factor Xa para establecer rango 
      terapeutico en tratamiento anticoagulante con heparina sodica.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
RN  - 0 (Anticoagulants)
RN  - 0 (Factor Xa Inhibitors)
RN  - 0 (Indicators and Reagents)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*administration & dosage
MH  - Factor Xa Inhibitors/*blood
MH  - Heparin/*administration & dosage
MH  - Humans
MH  - Indicators and Reagents
MH  - Nomograms
MH  - Partial Thromboplastin Time/*methods
MH  - Reference Standards
MH  - Reference Values
MH  - Regression Analysis
MH  - Reproducibility of Results
MH  - Time Factors
EDAT- 2015/02/20 06:00
MHDA- 2015/09/16 06:00
CRDT- 2015/02/20 06:00
PHST- 2014/03/05 00:00 [received]
PHST- 2014/10/15 00:00 [accepted]
PHST- 2015/02/20 06:00 [entrez]
PHST- 2015/02/20 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
AID - S0034-98872014001100005 [pii]
AID - 10.4067/S0034-98872014001100005 [doi]
PST - ppublish
SO  - Rev Med Chil. 2014 Nov;142(11):1392-7. doi: 10.4067/S0034-98872014001100005.