PMID- 25694589
OWN - NLM
STAT- MEDLINE
DCOM- 20150610
LR  - 20181113
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 89
IP  - 9
DP  - 2015 May
TI  - Maturation of human herpesvirus 6A glycoprotein O requires coexpression of 
      glycoprotein H and glycoprotein L.
PG  - 5159-63
LID - 10.1128/JVI.00140-15 [doi]
AB  - Glycoprotein O (gO) is conserved among betaherpesviruses, but little is known 
      about the maturation process of gO in human herpesvirus 6 (HHV-6). We found that 
      HHV-6 gO maturation was accompanied by cleavage of its carboxyl terminus and 
      required coexpression of gH and gL, which promoted the export of gO out of the 
      endoplasmic reticulum (ER). Finally, we also found that gO was not required for 
      HHV-6A growth in T cells.
CI  - Copyright (c) 2015, American Society for Microbiology. All Rights Reserved.
FAU - Tang, Huamin
AU  - Tang H
AD  - Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, 
      Japan.
FAU - Mahmoud, Nora F
AU  - Mahmoud NF
AD  - Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, 
      Japan Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
FAU - Mori, Yasuko
AU  - Mori Y
AD  - Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, 
      Japan ymori@med.kobe-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150218
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein L, herpesvirus 6)
RN  - 0 (glycoprotein O, herpesvirus 6)
RN  - 142985-75-9 (glycoprotein H, herpesvirus 6)
SB  - IM
MH  - Cells, Cultured
MH  - Gene Expression
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - *Protein Processing, Post-Translational
MH  - T-Lymphocytes/virology
MH  - Viral Envelope Proteins/*metabolism
MH  - *Virus Replication
PMC - PMC4403471
EDAT- 2015/02/20 06:00
MHDA- 2015/06/11 06:00
PMCR- 2015/11/01
CRDT- 2015/02/20 06:00
PHST- 2015/01/20 00:00 [received]
PHST- 2015/02/09 00:00 [accepted]
PHST- 2015/02/20 06:00 [entrez]
PHST- 2015/02/20 06:00 [pubmed]
PHST- 2015/06/11 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - JVI.00140-15 [pii]
AID - 00140-15 [pii]
AID - 10.1128/JVI.00140-15 [doi]
PST - ppublish
SO  - J Virol. 2015 May;89(9):5159-63. doi: 10.1128/JVI.00140-15. Epub 2015 Feb 18.