PMID- 25695438
OWN - NLM
STAT- MEDLINE
DCOM- 20150311
LR  - 20161021
IS  - 0894-203X (Print)
IS  - 0894-203X (Linking)
VI  - 30
IP  - 3
DP  - 2014
TI  - Detection and identification of platelet-associated alloantibodies by a 
      solid-phase modified antigen capture enzyme-linked immunosorbent assay method and 
      its correlation to platelet refractoriness in multiplatelet 
      concentrate-transfused patients.
PG  - 123-5
AB  - Platelets express a variety of polymorphic glycoproteins (GPs), such as 
      GPIIb/IIIa, GPib/IX, GPla/Ila, GPIV, and class I human leukocyte antigen. In the 
      platelet transfusion setting, alloimmunization involves the production of 
      antibodies against these glycoproteins. Patients transfused with multiple units 
      of platelet concentrates for longer periods are the main individuals with 
      platelet alloimmunization. This study was performed to detect the development of 
      platelet antibodies in patients who are transfused with multiple units of 
      leukodepleted platelet concentrates, such as those with hemato-oncologic diseases 
      and bone marrow failure syndromes. The method used was solid phase modified 
      antigen capture enzyme-linked immunosorbent assay. Platelet refractoriness was 
      assessed by measuring the corrected count increment at 1 and 24 hours after 
      transfusion.
FAU - Jain, Neelesh
AU  - Jain N
AD  - MD (corresponding author), Transfusion Medicine, Tata Medical Centre, Kolkata, 
      West Bengal-700156, India.
FAU - Sarkar, Shankar
AU  - Sarkar S
AD  - MD.
FAU - Philip, Joseph
AU  - Philip J
AD  - MD, Department of Immunohaematology and Blood Transfusion, Armed Forces Medical 
      College, Pune, India-411040.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Immunohematology
JT  - Immunohematology
JID - 8806387
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Antigens, Human Platelet/blood/*immunology
MH  - Blood Platelets/*immunology
MH  - Female
MH  - Hematologic Neoplasms/blood/immunology/therapy
MH  - Humans
MH  - Immunosorbent Techniques
MH  - Isoantibodies/blood/*immunology
MH  - Male
MH  - *Platelet Transfusion
MH  - Time Factors
EDAT- 2015/02/20 06:00
MHDA- 2015/03/12 06:00
CRDT- 2015/02/20 06:00
PHST- 2015/02/20 06:00 [entrez]
PHST- 2015/02/20 06:00 [pubmed]
PHST- 2015/03/12 06:00 [medline]
PST - ppublish
SO  - Immunohematology. 2014;30(3):123-5.