PMID- 25696171
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1568-5888 (Print)
IS  - 1568-5888 (Linking)
VI  - 11
IP  - 12
DP  - 2003 Dec
TI  - First Dutch experience with percutaneous left atrial appendage transcatheter 
      occlusion.
PG  - 506-509
AB  - BACKGROUND: Patients with atrial fibrillation (AF) have an increased risk of 
      thromboembolic stroke, dependent on clinical variables. Oral anticoagulation 
      significantly decreases the risk of stroke or embolism, but sometimes this is 
      difficult to manage and may be contraindicated. Approximately 90% of atrial 
      thrombi in nonrheumatic AF are found in the left atrial appendage (LAA). A new 
      device has been developed which allows percutaneous LAA occlusion (PLAATO) and 
      might be an alternative to oral anticoagulation. Feasibility in dogs and humans 
      was described previously. METHODS AND RESULTS: As part of an international 
      multicentre trial, three patients received a percutaneous transcatheter LAA 
      occlusion device. Implantations were performed without general anaesthesia, 
      guided by intracardiac and transoesophageal echocardiography and without major 
      complications. The implantations were well tolerated by the patients, who entered 
      a long-term follow-up to be compared with a historical control group. CONCLUSION: 
      Transseptal percutaneous LAA occlusion is feasible. Its role as an alternative to 
      oral anticoagulation, however, needs to be further defined.
FAU - Scholten, M F
AU  - Scholten MF
FAU - Jordaens, L J
AU  - Jordaens LJ
FAU - Cummins, P A
AU  - Cummins PA
FAU - Serruys, P W
AU  - Serruys PW
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neth Heart J
JT  - Netherlands heart journal : monthly journal of the Netherlands Society of 
      Cardiology and the Netherlands Heart Foundation
JID - 101095458
PMC - PMC2499961
OTO - NOTNLM
OT  - atrial fibrillation
OT  - left atrial appendage
OT  - occluder
OT  - thromboembolic risk
EDAT- 2003/12/01 00:00
MHDA- 2003/12/01 00:01
PMCR- 2003/12/01
CRDT- 2015/02/20 06:00
PHST- 2015/02/20 06:00 [entrez]
PHST- 2003/12/01 00:00 [pubmed]
PHST- 2003/12/01 00:01 [medline]
PHST- 2003/12/01 00:00 [pmc-release]
PST - ppublish
SO  - Neth Heart J. 2003 Dec;11(12):506-509.