PMID- 25696600
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1568-5888 (Print)
IS  - 1568-5888 (Linking)
VI  - 14
IP  - 3
DP  - 2006 Mar
TI  - Health-related quality of life relative to clinical outcomes in patients with 
      atrial fibrillation treated with ventricular rate stabilisation pacing.
PG  - 81-88
AB  - AIMS: It is uncertain whether patient perception of atrial fibrillation (AF) is 
      based on the fast ventricular rate as such or the irregularity of the ventricular 
      responses. This trial was designed to confirm the effectiveness of a ventricular 
      rate stabilisation (VRS) algorithm in reducing ventricular irregularity during 
      permanent pacing in patients with AF and to assess the patient preference and 
      effect on quality of life (QoL). METHODS: In this multicentre single-blind 
      randomised crossover trial, 184 patients with drug-refractory permanent (n=91) or 
      paroxysmal (n=93) AF received a VVI(R) or DDD(R) pacemaker respectively and were 
      paced in a randomised sequence with VRS on or off for two months. Clinical 
      assessments (QoL, New York Heart Association (NYHA) classification, 
      echocardiography, six-minute walk test and Holter recording) were carried out at 
      baseline, at randomisation and after each crossover period. QoL assessment was 
      performed using Aquarel, a new disease-specific QoL questionnaire for pacemaker 
      patients, the Short Form 36 survey (SF-36), the Duke Activity Status Index (DASI) 
      and the Symptom Checklist frequency and severity scores. At the end of the study 
      patients preferences for VRS-on or VRS-off were recorded. RESULTS: VRS pacing 
      reduced ventricular irregularity without increasing the mean ventricular rate. 
      VRS-on was preferred by 65.8% of patients with paroxysmal AF; patients with 
      permanent AF had no preference. QoL did not show improvement during VRS pacing on 
      any of the instruments. CONCLUSION: VRS pacing is effective in reducing 
      ventricular rhythm irregularity. QoL does not improve during VRS pacing but 
      preference for VRS pacing appears particularly outspoken for patients with 
      paroxysmal AF.
FAU - Stofmeel, M A M
AU  - Stofmeel MA
FAU - van Hemel, N M
AU  - van Hemel NM
FAU - Kelder, J C
AU  - Kelder JC
FAU - Yee, R
AU  - Yee R
FAU - Labonte, R E
AU  - Labonte RE
FAU - Taborsky, M
AU  - Taborsky M
FAU - Grobbee, D E
AU  - Grobbee DE
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neth Heart J
JT  - Netherlands heart journal : monthly journal of the Netherlands Society of 
      Cardiology and the Netherlands Heart Foundation
JID - 101095458
PMC - PMC2557280
OTO - NOTNLM
OT  - Aquarel
OT  - pacing
OT  - quality of life
OT  - rate stabilisation
EDAT- 2006/03/01 00:00
MHDA- 2006/03/01 00:01
PMCR- 2006/03/01
CRDT- 2015/02/20 06:00
PHST- 2015/02/20 06:00 [entrez]
PHST- 2006/03/01 00:00 [pubmed]
PHST- 2006/03/01 00:01 [medline]
PHST- 2006/03/01 00:00 [pmc-release]
PST - ppublish
SO  - Neth Heart J. 2006 Mar;14(3):81-88.