PMID- 2569683
OWN - NLM
STAT- MEDLINE
DCOM- 19890921
LR  - 20190919
IS  - 0161-6412 (Print)
IS  - 0161-6412 (Linking)
VI  - 11
IP  - 2
DP  - 1989 Jun
TI  - So-called intracranial germ cell tumours: personal experiences and a theory of 
      their pathogenesis.
PG  - 118-26
AB  - We investigated 110 cases of intracranial germ cell tumours (up to the end of 
      1986), 56% of which showed monotypic histological patterns and 44% were shown to 
      be mixed tumours. All these cases underwent surgery followed by radiation and/or 
      chemotherapy. All cases of choriocarcinoma and embryonal carcinoma died within 2 
      yr: cases of endodermal sinus tumour also showed poor results (4 yr survival rate 
      was 12.5%). Mature teratoma had a 5 yr survival rate (5YSR) and a 10 yr survival 
      rate (10YSR) of 78.3% each: immature teratoma showed a 5YSR of 44.9%. Two-cell 
      pattern tumours (PTC) showed a 5YSR of 85.8% and a 10YSR of 82.4%. They (PTC) can 
      be divided into two groups (i) germinoma and (ii) pinealoma of pineal parenchyma 
      origin (pineocytoma with lymphocytic infiltration) on the basis of the difference 
      in the tumour cell-stroma relationship and also placental alkaline phosphatase 
      stain. In the pineal region, 70% of PTC belonged to the category of pinealoma and 
      in the suprasellar region, 92% of PTC were germinoma. Germinoma showed a 5YSR of 
      91.4% and a 10YSR of 91.4%, whereas those of the pinealoma were 78.2% and 68.4% 
      respectively. This suggests that the biological characteristics of germinoma and 
      pinealoma may be different. All these results may bring into question the 
      validity of the germ cell theory, since germinoma, which should be the most 
      undifferentiated according to the theory, was the most benign and choriocarcinoma 
      and endodermal sinus tumour, which should be the most differentiated, were the 
      most malignant in the follow-up study.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Sano, K
AU  - Sano K
AD  - Department of Neurosurgery, University of Tokyo, Japan.
FAU - Matsutani, M
AU  - Matsutani M
FAU - Seto, T
AU  - Seto T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/etiology/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Germ Cell and Embryonal/etiology/*pathology
RF  - 39
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 10.1080/01616412.1989.11739874 [doi]
PST - ppublish
SO  - Neurol Res. 1989 Jun;11(2):118-26. doi: 10.1080/01616412.1989.11739874.