PMID- 25697068
OWN - NLM
STAT- MEDLINE
DCOM- 20160105
LR  - 20150522
IS  - 1601-5215 (Electronic)
IS  - 0924-2708 (Linking)
VI  - 27
IP  - 3
DP  - 2015 Jun
TI  - Chronic lipopolysaccharide infusion fails to induce depressive-like behaviour in 
      adult male rats.
PG  - 189-94
LID - 10.1017/neu.2015.4 [doi]
AB  - BACKGROUND: Chronic inflammation is implicated in numerous diseases, including 
      major depression and type 2 diabetes mellitus (T2DM). Since depression and T2DM 
      often co-exist, inflammatory pathways are suggested as a possible link. Hence, 
      the establishment of an immune-mediated animal model would shed light on 
      mechanisms possibly linking depression and metabolic alterations. OBJECTIVE: In 
      this study we investigated a behavioural and metabolic paradigm following chronic 
      infusion with low doses of lipopolysaccharide (LPS) using osmotic minipumps in 
      male rats. METHODS: Behavioural testing consisted of evaluating activity level in 
      the open field and depressive-like behaviour in the forced swim test. Metabolic 
      assessment included measurement of body weight, food and water intake, and 
      glucose and insulin levels during an oral glucose tolerance test. RESULTS: 
      LPS-infused rats showed acute signs of sickness behaviour, but chronic LPS 
      infusion did not induce behavioural or metabolic changes. CONCLUSION: These 
      results suggest that although inflammation is immediately induced as indicated by 
      acute sickness, 4 weeks of chronic LPS administration via osmotic minipumps did 
      not result in behavioural changes. Therefore, this paradigm may not be a suitable 
      model for studying the underlying mechanisms that link depression and T2DM.
FAU - Fischer, Christina Weide
AU  - Fischer CW
AD  - 1Translational Neuropsychiatry Unit,Aarhus University,Risskov,Denmark.
FAU - Liebenberg, Nico
AU  - Liebenberg N
AUID- ORCID: 0000-0001-9655-8911
AD  - 1Translational Neuropsychiatry Unit,Aarhus University,Risskov,Denmark.
FAU - Madsen, Anne Mette
AU  - Madsen AM
AD  - 2The National Research Centre for the Working Environment,Copenhagen,Denmark.
FAU - Muller, Heidi Kaastrup
AU  - Muller HK
AD  - 1Translational Neuropsychiatry Unit,Aarhus University,Risskov,Denmark.
FAU - Lund, Sten
AU  - Lund S
AD  - 3Medical Research Laboratory,Medical Department M (Endocrinology and 
      Diabetes),Aarhus University Hospital,Denmark.
FAU - Wegener, Gregers
AU  - Wegener G
AD  - 1Translational Neuropsychiatry Unit,Aarhus University,Risskov,Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150220
PL  - England
TA  - Acta Neuropsychiatr
JT  - Acta neuropsychiatrica
JID - 9612501
RN  - 0 (Cytokines)
RN  - 0 (Insulin)
RN  - 0 (Lipopolysaccharides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Body Weight/drug effects
MH  - Cytokines/metabolism
MH  - Depression/*chemically induced/diagnosis/metabolism/psychology
MH  - Disease Models, Animal
MH  - Frontal Lobe/drug effects/metabolism
MH  - Glucose/metabolism
MH  - Glucose Tolerance Test/methods
MH  - Insulin/metabolism
MH  - Lipopolysaccharides/*administration & dosage
MH  - Male
MH  - Motor Activity/drug effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - central nervous system
OT  - depression
OT  - neuroendocrinology
OT  - psychoneuroimmunology
EDAT- 2015/02/24 06:00
MHDA- 2016/01/06 06:00
CRDT- 2015/02/21 06:00
PHST- 2015/02/21 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2016/01/06 06:00 [medline]
AID - S0924270815000046 [pii]
AID - 10.1017/neu.2015.4 [doi]
PST - ppublish
SO  - Acta Neuropsychiatr. 2015 Jun;27(3):189-94. doi: 10.1017/neu.2015.4. Epub 2015 
      Feb 20.