PMID- 25698601
OWN - NLM
STAT- MEDLINE
DCOM- 20151207
LR  - 20150321
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 284
DP  - 2015 May 1
TI  - Chronic acarbose treatment alleviates age-related behavioral and biochemical 
      changes in SAMP8 mice.
PG  - 138-52
LID - S0166-4328(15)00091-1 [pii]
LID - 10.1016/j.bbr.2015.01.052 [doi]
AB  - The administration of maintaining the homeostasis of insulin/insulin-like growth 
      factor 1 (IGF-1) signaling and/or glucose metabolism may reverse brain aging. In 
      the present study, we investigated the effect of acarbose, an inhibitor of 
      alpha-glucosidase, on age-related behavioral and biochemical changes. The SAMP8 mice 
      were randomly divided into old control group and acarbose-treatment group. The 
      mice in the acarbose group were administered acarbose (20 mg/kg/d, dissolved in 
      drinking water) orally from 3 to 9 months of age when a new group of 3-month-old 
      mice was added as young controls. The results showed that the aged controls 
      exhibited declines in sensorimotor ability, open field anxiety, spatial and 
      non-spatial memory abilities, decreased serum insulin levels, increased IGF-1 
      receptor and synaptotagmin 1 (Syt1) levels and decreased insulin receptor, 
      brain-derived neurotrophic factor (BDNF) and syntaxin 1 (Stx1) levels in the 
      hippocampal layers. The age-related behavioral deficits correlated with the 
      serological and histochemical data. Chronic acarbose treatment relieved these 
      age-related changes, especially with respect to learning and memory abilities. 
      This protective effect of acarbose on age-related behavioral impairments might be 
      related to changes in the insulin system and the levels of BDNF, IGF-1R, and the 
      pre-synaptic proteins Syt1 and Stx1. In conclusion, long-term treatment with 
      acarbose ameliorated the behavioral deficits and biochemical changes in old SAMP8 
      mice and promoted successful aging. This study provides insight into the 
      potential of acarbose for the treatment of brain aging.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Tong, Jing-Jing
AU  - Tong JJ
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, Anhui Province, PR China.
FAU - Chen, Gui-Hai
AU  - Chen GH
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, Anhui Province, PR China; Department of Neurology, The 
      First People's Hospital of Chenzhou, Southern Medical University, Chenzhou 
      423000, Hunan Province, PR China; School of Biotechnology and Food Engineering, 
      Hefei University of Technology, Hefei 230009, PR China. Electronic address: 
      doctorcgh@163.com.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, Anhui Province, PR China.
FAU - Li, Xue-Wei
AU  - Li XW
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, Anhui Province, PR China.
FAU - Cao, Lei
AU  - Cao L
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, Anhui Province, PR China.
FAU - Sui, Xu
AU  - Sui X
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, Anhui Province, PR China.
FAU - Tao, Fei
AU  - Tao F
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, Anhui Province, PR China.
FAU - Yan, Wen-Wen
AU  - Yan WW
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei 230022, Anhui Province, PR China.
FAU - Wei, Zhao-Jun
AU  - Wei ZJ
AD  - School of Biotechnology and Food Engineering, Hefei University of Technology, 
      Hefei 230009, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150216
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drinking Water)
RN  - 0 (Glycoside Hydrolase Inhibitors)
RN  - 0 (Insulin)
RN  - 0 (Psychotropic Drugs)
RN  - 0 (Synaptotagmin I)
RN  - 0 (Syntaxin 1)
RN  - 0 (Syt1 protein, mouse)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - T58MSI464G (Acarbose)
SB  - IM
MH  - Acarbose/*pharmacology
MH  - Administration, Oral
MH  - Aging/*drug effects/*metabolism/pathology/psychology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/blood/metabolism
MH  - Drinking Water
MH  - Female
MH  - Glycoside Hydrolase Inhibitors/*pharmacology
MH  - Hippocampus/drug effects/pathology/physiology
MH  - Insulin/blood
MH  - Male
MH  - Memory/drug effects/physiology
MH  - Mice
MH  - Motor Activity/drug effects/physiology
MH  - Psychotropic Drugs/*pharmacology
MH  - Random Allocation
MH  - Receptor, IGF Type 1/metabolism
MH  - Receptor, Insulin/metabolism
MH  - Synaptotagmin I/metabolism
MH  - Syntaxin 1/metabolism
OTO - NOTNLM
OT  - Acarbose
OT  - BDNF
OT  - Brain aging
OT  - Insulin
OT  - Insulin-like growth factor 1
OT  - Memory
EDAT- 2015/02/24 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/21 06:00
PHST- 2014/11/19 00:00 [received]
PHST- 2015/01/26 00:00 [revised]
PHST- 2015/01/30 00:00 [accepted]
PHST- 2015/02/21 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0166-4328(15)00091-1 [pii]
AID - 10.1016/j.bbr.2015.01.052 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 May 1;284:138-52. doi: 10.1016/j.bbr.2015.01.052. Epub 2015 
      Feb 16.