PMID- 25698958
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150220
LR  - 20201001
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 9
DP  - 2015
TI  - Safety and tolerability of theta burst stimulation vs. single and paired pulse 
      transcranial magnetic stimulation: a comparative study of 165 pediatric subjects.
PG  - 29
LID - 10.3389/fnhum.2015.00029 [doi]
LID - 29
AB  - BACKGROUND: Although single- and paired-pulse (sp/pp) transcranial magnetic 
      stimulation (TMS) studies are considered minimal risk in adults and children, the 
      safety profile for theta-burst TMS (TBS) is unknown. OBJECTIVE: In this 
      comparative analysis, we explored the rate, severity, and specific symptoms of 
      TMS-related adverse effects (AEs) between sp/ppTMS and TBS in subjects between 
      ages 6 and 18 years. METHOD: Data from 165 participants from 2009 to 2014 were 
      analyzed. Assessment of AEs was performed based on baseline and post-TMS 
      administration of a symptom-based questionnaire that rated AEs on a 5-level 
      ordinal scale (minimal, mild, moderate, marked, severe). AE rates and severity 
      were compared using Chi Square or Fisher's Exact Test depending on data 
      characteristics. RESULT: Overall, no seizures or severe-rated AEs were reported 
      by 165 pediatric participants. The rate of AE in all TBS sessions was 10.5% (n = 
      76, 95% CI: 4.7-19.7%), whereas the rate of AE in all sp/ppTMS sessions was 12.4% 
      (n = 89, 95% CI: 6.3-21.0%). There was no statistical difference in AE rates 
      between TBS and sp/ppTMS (p = 0.71). In all sp/ppTMS and TBS sessions, 20 
      subjects reported a total of 35 AEs, among these 31 (~88.6%) were rated as 
      "minimal" or "mild". There was no difference in the severity of AE between TBS 
      and sp/ppTMS (p = 1.0). Only one of 76 TBS participants reported an AE rated as 
      more than minimal/mild. CONCLUSION: Our comparative analysis showed that TBS 
      appears to be as safe as sp/ppTMS in terms of AE rate and severity. This report 
      supports further investigation of TBS in children.
FAU - Hong, Yaejee H
AU  - Hong YH
AD  - College of Medicine, University of Cincinnati Cincinnati, OH, USA.
FAU - Wu, Steve W
AU  - Wu SW
AD  - Division of Neurology, Cincinnati Children's Hospital Medical Center Cincinnati, 
      OH, USA.
FAU - Pedapati, Ernest V
AU  - Pedapati EV
AD  - Division of Neurology, Cincinnati Children's Hospital Medical Center Cincinnati, 
      OH, USA ; Division of Psychiatry, Cincinnati Children's Hospital Medical Center 
      Cincinnati, OH, USA.
FAU - Horn, Paul S
AU  - Horn PS
AD  - Division of Neurology, Cincinnati Children's Hospital Medical Center Cincinnati, 
      OH, USA.
FAU - Huddleston, David A
AU  - Huddleston DA
AD  - Division of Neurology, Cincinnati Children's Hospital Medical Center Cincinnati, 
      OH, USA.
FAU - Laue, Cameron S
AU  - Laue CS
AD  - Division of Psychiatry, Cincinnati Children's Hospital Medical Center Cincinnati, 
      OH, USA.
FAU - Gilbert, Donald L
AU  - Gilbert DL
AD  - Division of Neurology, Cincinnati Children's Hospital Medical Center Cincinnati, 
      OH, USA.
LA  - eng
GR  - R01 MH078160/MH/NIMH NIH HHS/United States
GR  - R01 MH081854/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20150204
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC4316715
OTO - NOTNLM
OT  - children
OT  - repetitive transcranial magnetic stimulation
OT  - safety
OT  - theta burst stimulation
OT  - transcranial magnetic stimulation
OT  - youth
EDAT- 2015/02/24 06:00
MHDA- 2015/02/24 06:01
PMCR- 2015/01/01
CRDT- 2015/02/21 06:00
PHST- 2014/12/23 00:00 [received]
PHST- 2015/01/12 00:00 [accepted]
PHST- 2015/02/21 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2015/02/24 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2015.00029 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2015 Feb 4;9:29. doi: 10.3389/fnhum.2015.00029. eCollection 
      2015.