PMID- 25699481
OWN - NLM
STAT- MEDLINE
DCOM- 20160609
LR  - 20150917
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Linking)
VI  - 47
IP  - 10
DP  - 2015 Oct
TI  - Exercise Enhances the Behavioral Responses to Acute Stress in an Animal Model of 
      PTSD.
PG  - 2043-52
LID - 10.1249/MSS.0000000000000642 [doi]
AB  - INTRODUCTION: This study examined the effects of endurance exercise on the 
      behavioral response to stress and patterns of brain-derived neurotrophic factor 
      (BDNF), neuropeptide Y (NPY), and delta-opioid receptor (phospho-DOR) expression in 
      the hippocampus. METHODS: Animals ran on a treadmill at 15 m.min, 5 min.d 
      gradually increasing to 20 min.d, 5 d.wk for 6 wk. After training, one group of 
      animals was exposed to a predator scent stress (PSS) protocol for 10 min. Outcome 
      measurements included behavior in an elevated plus-maze (EPM) and acoustic 
      startle response (ASR) 7 d after exposure to stress. Immunohistochemical 
      technique was used to detect the expression of the BDNF, NPY, and phospho-DOR in 
      the hippocampus 8 d after exposure. RESULTS: Sedentary animals exposed to PSS 
      were observed to have a greater incidence of extreme behavior responses including 
      higher anxiety, less total activity in the EPM, and greater amplitude in the ASR 
      than unexposed and/or trained animals. Exercise-trained animals exposed to PSS 
      developed a resiliency to the stress, reflected by significantly greater total 
      activity in the EPM, reduced anxiety, and reduced ASR compared to the sedentary, 
      exposed animals. Exercise in the absence of stress significantly elevated the 
      expression of BDNF and phospho-DOR, whereas exposure to PSS resulted in a 
      significant decline in the expression of NPY, BDNF, and phospho-DOR. Trained 
      animals that were exposed maintained expression of BDNF, NPY, and phospho-DOR in 
      most subregions of the hippocampus. CONCLUSION: Results indicated that endurance 
      training provided a mechanism to promote resilience and/or recovery from stress. 
      In addition, exercise increased expression of BDNF, NPY, and DOR signaling in the 
      hippocampus that was associated with the greater resiliency seen in the trained 
      animals.
FAU - Hoffman, Jay R
AU  - Hoffman JR
AD  - 1Institute of Exercise Physiology and Wellness, Sport and Exercise Science, 
      University of Central Florida, Orlando, FL; 2Israel Defense Force, Medical Corps, 
      Tel Hashomer, ISRAEL; 3Anxiety and Stress Research Unit, Beer-Sheva Mental Health 
      Center, Faculty of Health Sciences, Division of Psychiatry, Ben-Gurion University 
      of the Negev, Beer-Sheva, ISRAEL; and 4The State of Israel Ministry of Health, 
      The Chaim Sheba Medical Center, Division of Psychiatry, Ramat-Gan, Israel, 
      Sackler Medical School, Tel-Aviv University, ISRAEL.
FAU - Ostfeld, Ishay
AU  - Ostfeld I
FAU - Kaplan, Zeev
AU  - Kaplan Z
FAU - Zohar, Joseph
AU  - Zohar J
FAU - Cohen, Hagit
AU  - Cohen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Receptors, Opioid, delta)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Disease Models, Animal
MH  - Exercise/physiology/*psychology
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Male
MH  - Maze Learning
MH  - Neuropeptide Y/metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, Opioid, delta/metabolism
MH  - Reflex, Startle
MH  - Stress Disorders, Post-Traumatic/metabolism/*psychology
MH  - Stress, Psychological
EDAT- 2015/02/24 06:00
MHDA- 2016/06/10 06:00
CRDT- 2015/02/21 06:00
PHST- 2015/02/21 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2016/06/10 06:00 [medline]
AID - 10.1249/MSS.0000000000000642 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2015 Oct;47(10):2043-52. doi: 10.1249/MSS.0000000000000642.