PMID- 25699980
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20150221
IS  - 1533-0311 (Electronic)
IS  - 0193-1091 (Linking)
VI  - 37
IP  - 3
DP  - 2015 Mar
TI  - Merkel cell carcinoma with glandular differentiation admixed with sweat gland 
      carcinoma and spindle cell carcinoma: histogenesis of merkel cell carcinoma from 
      hair follicle stem cells.
PG  - e31-6
LID - 10.1097/DAD.0000000000000064 [doi]
AB  - We describe a unique case of Merkel cell carcinoma (MCC) with a heterogeneous 
      differentiation exhibiting distinct triphasic phenotypic differentiation 
      features: small cells typical of MCC, sweat gland carcinoma (sweat gland Ca.) 
      with possible decapitation secretion, and spindle cell carcinoma (spindle cell 
      Ca.). The patient was an 84-year-old Japanese woman. We evaluated the present 
      case immunohistochemically with various antibodies. The histological features 
      showed a gradual transition from MCC to sweat gland Ca. and spindle cell Ca. For 
      clarifying the histogenesis, immunophenotypic analysis of the 3 different 
      components of the carcinoma was performed using hair follicle stem cell markers 
      (eg, CK15, CK19, and CD200) that have been identified as biomarkers of human 
      bulge cells. The triphasic components immunohistochemically shared the 
      characteristic feature of CK19 and CD200 expression. We posit that the MCC arose 
      from hair follicle stem cells residing within the bulge area where Merkel cells 
      are preferentially situated. Based on our findings, we recommend adding this rare 
      neoplasm to the expanding morphological spectrum of MCC.
FAU - Koba, Shinichi
AU  - Koba S
AD  - *Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, 
      Saga University, Saga, Japan; and daggerDepartment of Pathology and Microbiology, 
      Faculty of Medicine, Saga University, Saga, Japan.
FAU - Nagase, Kotaro
AU  - Nagase K
FAU - Ikeda, Satoshi
AU  - Ikeda S
FAU - Aoki, Shigehisa
AU  - Aoki S
FAU - Misago, Noriyuki
AU  - Misago N
FAU - Narisawa, Yutaka
AU  - Narisawa Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
SB  - IM
MH  - Aged, 80 and over
MH  - Carcinoma, Merkel Cell/*pathology
MH  - Carcinoma, Skin Appendage/pathology
MH  - *Cell Differentiation
MH  - Female
MH  - Hair Follicle/*pathology
MH  - Humans
MH  - Skin Neoplasms/*pathology
MH  - Stem Cells/pathology
MH  - Sweat Gland Neoplasms/pathology
EDAT- 2015/02/24 06:00
MHDA- 2015/09/01 06:00
CRDT- 2015/02/21 06:00
PHST- 2015/02/21 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 00000372-201503000-00016 [pii]
AID - 10.1097/DAD.0000000000000064 [doi]
PST - ppublish
SO  - Am J Dermatopathol. 2015 Mar;37(3):e31-6. doi: 10.1097/DAD.0000000000000064.