PMID- 25700666
OWN - NLM
STAT- MEDLINE
DCOM- 20151207
LR  - 20220316
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 284
DP  - 2015 May 1
TI  - Early constraint-induced movement therapy promotes functional recovery and 
      neuronal plasticity in a subcortical hemorrhage model rat.
PG  - 158-66
LID - S0166-4328(15)00101-1 [pii]
LID - 10.1016/j.bbr.2015.02.022 [doi]
AB  - Constraint-induced movement therapy (CIMT) promotes functional recovery of 
      impaired forelimbs after hemiplegic strokes, including intracerebral hemorrhage 
      (ICH). We used a rat model of subcortical hemorrhage to compare the effects of 
      delivering early or late CIMT after ICH. The rat model was made by injecting 
      collagenase into the globus pallidus near the internal capsule, and then forcing 
      rats to use the affected forelimb for 7 days starting either 1 day (early CIMT) 
      or 17 days (late CIMT) after the lesion. Recovery of forelimb function in the 
      skilled reaching test and the ladder stepping test was found after early-CIMT, 
      while no significant recovery was shown after late CIMT or in the non-CIMT 
      controls. Early CIMT was associated with greater numbers of DeltaFosB-positive cells 
      in the ipsi-lesional sensorimotor cortex layers II-III and V. Additionally, we 
      found expression of the growth-related genes brain-derived neurotrophic factor 
      (BDNF) and growth-related protein 43 (GAP-43), and abundant dendritic 
      arborization of pyramidal neurons in the sensorimotor area. Similar results were 
      not detected in the contra-lesional cortex. In contrast to early CIMT, late CIMT 
      failed to induce any changes in plasticity. We conclude that CIMT induces 
      molecular and morphological plasticity in the ipsi-lesional sensorimotor cortex 
      and facilitates better functional recovery when initiated immediately after 
      hemorrhage.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ishida, Akimasa
AU  - Ishida A
AD  - Department of Neurophysiology and Brain Science, Nagoya City University Graduate 
      School of Medicine, Nagoya, Aichi 467-8601, Japan; Department of Physical 
      Therapy, Program in Physical and Occupational Therapy, Nagoya University Graduate 
      School of Medicine, Nagoya, Aichi 461-8673, Japan.
FAU - Misumi, Sachiyo
AU  - Misumi S
AD  - Department of Neurophysiology and Brain Science, Nagoya City University Graduate 
      School of Medicine, Nagoya, Aichi 467-8601, Japan.
FAU - Ueda, Yoshitomo
AU  - Ueda Y
AD  - Department of Neurophysiology and Brain Science, Nagoya City University Graduate 
      School of Medicine, Nagoya, Aichi 467-8601, Japan.
FAU - Shimizu, Yuko
AU  - Shimizu Y
AD  - Department of Neurophysiology and Brain Science, Nagoya City University Graduate 
      School of Medicine, Nagoya, Aichi 467-8601, Japan.
FAU - Cha-Gyun, Jung
AU  - Cha-Gyun J
AD  - Department of Neurophysiology and Brain Science, Nagoya City University Graduate 
      School of Medicine, Nagoya, Aichi 467-8601, Japan.
FAU - Tamakoshi, Keigo
AU  - Tamakoshi K
AD  - Department of Physical Therapy, Program in Physical and Occupational Therapy, 
      Nagoya University Graduate School of Medicine, Nagoya, Aichi 461-8673, Japan.
FAU - Ishida, Kazuto
AU  - Ishida K
AD  - Department of Physical Therapy, Program in Physical and Occupational Therapy, 
      Nagoya University Graduate School of Medicine, Nagoya, Aichi 461-8673, Japan.
FAU - Hida, Hideki
AU  - Hida H
AD  - Department of Neurophysiology and Brain Science, Nagoya City University Graduate 
      School of Medicine, Nagoya, Aichi 467-8601, Japan. Electronic address: 
      hhida@med.nagoya-cu.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150217
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fosb protein, rat)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - EC 3.4.24.- (Collagenases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Hemorrhage/pathology/physiopathology/*rehabilitation
MH  - Collagenases
MH  - Dendrites/pathology/physiology
MH  - Exercise Therapy/*methods
MH  - Forelimb/*physiopathology
MH  - Functional Laterality/physiology
MH  - GAP-43 Protein/metabolism
MH  - Globus Pallidus
MH  - Male
MH  - Motor Skills/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Pyramidal Cells/pathology/physiology
MH  - Rats, Wistar
MH  - Recovery of Function/*physiology
MH  - Sensorimotor Cortex/pathology/*physiopathology
MH  - Time Factors
OTO - NOTNLM
OT  - Forelimb function
OT  - Growth factor
OT  - Intracerebral hemorrhage
OT  - Plasticity
OT  - Rat
OT  - Rehabilitation
EDAT- 2015/02/24 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/22 06:00
PHST- 2014/12/05 00:00 [received]
PHST- 2015/02/04 00:00 [revised]
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/02/22 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0166-4328(15)00101-1 [pii]
AID - 10.1016/j.bbr.2015.02.022 [doi]
PST - ppublish
SO  - Behav Brain Res. 2015 May 1;284:158-66. doi: 10.1016/j.bbr.2015.02.022. Epub 2015 
      Feb 17.