PMID- 25700727
OWN - NLM
STAT- MEDLINE
DCOM- 20160201
LR  - 20220330
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Print)
IS  - 0022-3999 (Linking)
VI  - 79
IP  - 2
DP  - 2015 Aug
TI  - Comorbidity of mood and substance use disorders in patients with binge-eating 
      disorder: Associations with personality disorder and eating disorder pathology.
PG  - 159-64
LID - S0022-3999(15)00031-8 [pii]
LID - 10.1016/j.jpsychores.2015.01.016 [doi]
AB  - OBJECTIVE: Binge-eating disorder (BED) is associated with elevated rates of mood 
      and substance use disorders, but the significance of such comorbidity is 
      ambiguous. We compared personality disorder and eating disorder psychopathology 
      in four subgroups of BED patients: those with mood disorders, those with 
      substance use disorders, those with both, and those with neither. METHOD: 
      Subjects were 347 patients who met DSM-IV research criteria for BED. 
      Semistructured interviews evaluated lifetime DSM-IV axis I disorders, DSM-IV 
      personality disorder features, and eating disorder psychopathology. RESULTS: 
      Among these patients, 129 had co-occurring mood disorder, 34 had substance use 
      disorder, 60 had both, and 124 had neither. Groups differed on personality 
      disorder features, with those having mood disorder and both mood and substance 
      use disorders showing the highest frequencies. Although groups did not differ in 
      body mass index or binge eating frequency, they did differ on eating disorder 
      psychopathology-with the groups having mood disorder and both comorbidities 
      demonstrating higher eating, weight, and shape concerns. No differences were 
      observed between groups with respect to ages of onset for specific eating 
      behaviors, but some differences were observed for ages of disorder onset. 
      CONCLUSION: Mood and substance use disorders co-occur frequently among patients 
      with BED. Compared with a previous work, the additional comparison group (those 
      with both mood and substance use disorders) and the control group (those with 
      neither) afforded better discrimination regarding the significance of these 
      comorbidities. Our findings suggest approaches to subtyping BED based on 
      psychiatric comorbidity, and may also have implications for treatment.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Becker, Daniel F
AU  - Becker DF
AD  - Department of Psychiatry, University of California, San Francisco, USA. 
      Electronic address: beckerdf@sutterhealth.org.
FAU - Grilo, Carlos M
AU  - Grilo CM
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
LA  - eng
GR  - K24 DK070052/DK/NIDDK NIH HHS/United States
GR  - R01 DK049587/DK/NIDDK NIH HHS/United States
GR  - 3R01 DK49587/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150207
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Binge-Eating Disorder/complications/*psychology
MH  - Body Mass Index
MH  - Body Weight
MH  - Comorbidity
MH  - Diagnosis, Dual (Psychiatry)
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Eating
MH  - Feeding and Eating Disorders/complications/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mood Disorders/complications/*psychology
MH  - Personality Disorders/complications/*psychology
MH  - Substance-Related Disorders/complications/*psychology
MH  - Young Adult
PMC - PMC4492840
MID - NIHMS665441
OTO - NOTNLM
OT  - Binge-eating disorder
OT  - Comorbidity
OT  - Depression
OT  - Diagnostic subtyping
OT  - Obesity
OT  - Substance use disorders
COIS- Conflict of Interest The authors have no competing interests to report.
EDAT- 2015/02/24 06:00
MHDA- 2016/02/02 06:00
PMCR- 2016/08/01
CRDT- 2015/02/22 06:00
PHST- 2014/08/12 00:00 [received]
PHST- 2015/01/24 00:00 [revised]
PHST- 2015/01/31 00:00 [accepted]
PHST- 2015/02/22 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2016/02/02 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - S0022-3999(15)00031-8 [pii]
AID - 10.1016/j.jpsychores.2015.01.016 [doi]
PST - ppublish
SO  - J Psychosom Res. 2015 Aug;79(2):159-64. doi: 10.1016/j.jpsychores.2015.01.016. 
      Epub 2015 Feb 7.