PMID- 25700843
OWN - NLM
STAT- MEDLINE
DCOM- 20160929
LR  - 20181113
IS  - 1436-2813 (Electronic)
IS  - 0941-1291 (Linking)
VI  - 46
IP  - 2
DP  - 2016 Feb
TI  - Influence of smoking on perioperative oxidative stress after pulmonary resection.
PG  - 183-7
LID - 10.1007/s00595-015-1132-4 [doi]
AB  - PURPOSE: We herein investigated the influence of smoking on changes in the levels 
      of perioperative oxidative stress after pulmonary resection. METHODS: A total of 
      31 patients with primary lung cancer who underwent curative pulmonary lobectomy 
      were analyzed prospectively. The degree of perioperative oxidative stress was 
      evaluated based on the serum levels of derivatives of reactive oxygen metabolites 
      (d-ROM) and biological antioxidant potential (BAP). The patients were divided 
      into two groups: group A (smoking < 40 pack-years) and group B (smoking >/= 40 
      pack-years). The d-ROM and BAP measurements were obtained preoperatively, 
      postoperatively and on the first, second, third and fifth postoperative days. 
      RESULTS: In all 31 cases, the d-ROM values were higher on the third and fifth 
      postoperative days than preoperatively. The extent of change in the d-ROM levels 
      was greater in group A than in group B on the second, third and fifth 
      postoperative days (1.05 +/- 0.159 vs. 0.920 +/- 0.205, p = 0.008; 1.20 +/- 0.233 vs. 
      1.02 +/- 0.186, p = 0.032; 1.34 +/- 0.228 vs. 1.07 +/- 0.200, p = 0.003, respectively). 
      In contrast, there were no significant differences in the BAP values. The maximum 
      increase in the d-ROM level and decrease in the BAP level negatively correlated 
      with the amount of smoking (|r| = 0.428, p = 0.016 and |r| = 0.357. p = 0.049, 
      respectively). CONCLUSIONS: Surgical stress associated with pulmonary lobectomy 
      induces oxidative stress. In addition, smoking reduces the oxidative stress 
      reaction, and the degree of this change is correlated with the amount of smoking.
FAU - Mizuno, Yoshimasa
AU  - Mizuno Y
AD  - Department of General and Cardiothoracic Surgery, Graduate School of Medicine, 
      Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
FAU - Iwata, Hisashi
AU  - Iwata H
AD  - Department of General and Cardiothoracic Surgery, Graduate School of Medicine, 
      Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan. 
      ihisashi@gifu-u.ac.jp.
FAU - Yamamoto, Hirotaka
AU  - Yamamoto H
AD  - Department of General and Cardiothoracic Surgery, Graduate School of Medicine, 
      Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
FAU - Miyamoto, Yusaku
AU  - Miyamoto Y
AD  - Department of General and Cardiothoracic Surgery, Graduate School of Medicine, 
      Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
FAU - Mitta, Shohei
AU  - Mitta S
AD  - Department of General and Cardiothoracic Surgery, Graduate School of Medicine, 
      Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
FAU - Shirahashi, Koyo
AU  - Shirahashi K
AD  - Department of General and Cardiothoracic Surgery, Graduate School of Medicine, 
      Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
FAU - Takemura, Hirofumi
AU  - Takemura H
AD  - Department of General and Cardiothoracic Surgery, Graduate School of Medicine, 
      Gifu University, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150221
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/analysis
MH  - Biomarkers/blood
MH  - Humans
MH  - Lung Neoplasms/surgery
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - *Perioperative Period
MH  - *Pneumonectomy
MH  - Prospective Studies
MH  - Reactive Oxygen Species/blood
MH  - *Smoking/blood/physiopathology
MH  - Time Factors
OTO - NOTNLM
OT  - Oxidative stress
OT  - Pulmonary resection
OT  - Smoking
EDAT- 2015/02/24 06:00
MHDA- 2016/09/30 06:00
CRDT- 2015/02/22 06:00
PHST- 2014/06/23 00:00 [received]
PHST- 2015/01/30 00:00 [accepted]
PHST- 2015/02/22 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2016/09/30 06:00 [medline]
AID - 10.1007/s00595-015-1132-4 [pii]
AID - 10.1007/s00595-015-1132-4 [doi]
PST - ppublish
SO  - Surg Today. 2016 Feb;46(2):183-7. doi: 10.1007/s00595-015-1132-4. Epub 2015 Feb 
      21.