PMID- 25701473 OWN - NLM STAT- MEDLINE DCOM- 20150709 LR - 20181202 IS - 1573-2959 (Electronic) IS - 0167-6369 (Linking) VI - 187 IP - 3 DP - 2015 Mar TI - Blood levels of polychlorinated biphenlys and organochlorinated pesticides in women from Istanbul, Turkey. PG - 132 LID - 10.1007/s10661-015-4358-0 [doi] AB - The human body is not a chemically uncontaminated system. Every simple action that humans undertake, such as drinking water, eating, nursing, and even breathing air, puts the system under environmental xenobiotic exposure stress. Environmental chemicals have been shown to produce unwanted effects on health and remove the right to healthy living, starting from the first encounter in utero to geriatrics, throughout the lifespan. Organochlorine pesticides (OCPs) and polychlorinated biphenyl (PCB) levels, important members of the persistent organic pollutants (POPs), have been detected before in human breast milk and also in the adipose tissue of women from different regions of Turkey; however, there was no information about the blood levels of these chemicals. This study generated the first information that evaluates OCP and PCB contamination levels in the blood of the women living in Turkey. The current study measured the blood concentrations of OCPs and PCBs in 58 healthy women (age 20-41 years; mean age 28 years) who were living in Istanbul, Turkey, in the years 2010-2012. Samples were analyzed for 29 OCPs and 18 PCB congeners using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). PCB 153 was the predominant congener (643.2 pg/g lipid), followed by PCB 138 and PCB 180. 4,4'-DDE (24872.8 pg/g lipid) was the most common organochlorinated pesticide contaminant in studied blood samples. Results for analyzed chlorinated compounds were as follows: summation operatorPCB 2682 +/- 3300 pg/g lipid; summation operatorDDT 25,938 +/- 28,644 pg/g lipid; and summation operatorHCH 2930 +/- 2222 pg/g lipid, respectively. The mean concentration of summation operatorWHOPCB-TEQ was 0.037 pg/g on a lipid basis. This information will be important base data during the assessment of the general health concerns of women, as well as for studies about how endocrine disruptors affect humans for forthcoming studies. FAU - Ulutas, Onur Kenan AU - Ulutas OK AD - Department of Toxicology, Gazi University, Faculty of Pharmacy, 06330, Hipodrom, Ankara, Turkey, onurkenan@gmail.com. FAU - Cok, Ismet AU - Cok I FAU - Darendeliler, Feyza AU - Darendeliler F FAU - Aydin, Banu AU - Aydin B FAU - Coban, Asuman AU - Coban A FAU - Henkelmann, Bernhard AU - Henkelmann B FAU - Schramm, Karl-Werner AU - Schramm KW LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150221 PL - Netherlands TA - Environ Monit Assess JT - Environmental monitoring and assessment JID - 8508350 RN - 0 (Endocrine Disruptors) RN - 0 (Environmental Pollutants) RN - 0 (Hazardous Substances) RN - 0 (Hydrocarbons, Chlorinated) RN - 0 (Lipids) RN - 0 (Pesticides) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adipose Tissue MH - Adult MH - Air/analysis MH - Breast Feeding MH - Endocrine Disruptors/analysis/blood MH - Environmental Exposure/analysis/*statistics & numerical data MH - Environmental Monitoring MH - Environmental Pollutants/analysis/*blood MH - Female MH - Gas Chromatography-Mass Spectrometry MH - Halogenation MH - Hazardous Substances/analysis MH - Humans MH - Hydrocarbons, Chlorinated/analysis/*blood MH - Lipids/analysis MH - Pesticides/analysis MH - Polychlorinated Biphenyls/analysis/*blood MH - Turkey EDAT- 2015/02/24 06:00 MHDA- 2015/07/15 06:00 CRDT- 2015/02/22 06:00 PHST- 2014/10/22 00:00 [received] PHST- 2015/02/09 00:00 [accepted] PHST- 2015/02/22 06:00 [entrez] PHST- 2015/02/24 06:00 [pubmed] PHST- 2015/07/15 06:00 [medline] AID - 10.1007/s10661-015-4358-0 [doi] PST - ppublish SO - Environ Monit Assess. 2015 Mar;187(3):132. doi: 10.1007/s10661-015-4358-0. Epub 2015 Feb 21.