PMID- 25702806
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20150923
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 52
IP  - 4
DP  - 2015 Oct
TI  - Electrical impedance myography in Duchenne muscular dystrophy and healthy 
      controls: A multicenter study of reliability and validity.
PG  - 592-7
LID - 10.1002/mus.24611 [doi]
AB  - INTRODUCTION: Electrical impedance myography (EIM) is a non-invasive, painless, 
      objective technique to quantify muscle pathology. METHODS: We measured EIM in 8 
      arm and leg muscles in 61 boys with Duchenne muscular dystrophy (DMD) and 31 
      healthy boys, ages 3-12 years, at 5 centers. We determined the reliability of EIM 
      and compared results in boys with DMD to controls and to 6-minute walk distance 
      (6MWD), North Star Ambulatory Assessment (NSAA), timed functional tests (TFTs), 
      and strength (hand-held dynamometry). RESULTS: EIM was well tolerated and had 
      good inter- and intrarater reliability (intraclass correlation coefficient 
      0.81-0.96). The averaged EIM phase value from all muscles was higher (P < 0.001) 
      in controls (10.45 +/- 2.29) than boys with DMD (7.31 +/- 2.23), and correlated (P </= 
      0.001) with 6MWD (r = 0.55), NSAA (r = 0.66), TFTs (r = -0.56), and strength (r = 
      0.44). CONCLUSION: EIM is a reliable and valid measure of disease severity in 
      DMD. Longitudinal studies comparing EIM with other assessments over time in DMD 
      are warranted.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Zaidman, Craig M
AU  - Zaidman CM
AD  - Department of Neurology, Washington University School of Medicine, 660 South 
      Euclid Avenue, Box 8111, St. Louis, Missouri, 63110, USA.
AD  - Department of Pediatrics, Washington University School of Medicine, St. Louis, 
      Missouri, USA.
FAU - Wang, Lucy L
AU  - Wang LL
AD  - Skulpt, Inc, Boston, Massachusetts, USA.
FAU - Connolly, Anne M
AU  - Connolly AM
AD  - Department of Neurology, Washington University School of Medicine, 660 South 
      Euclid Avenue, Box 8111, St. Louis, Missouri, 63110, USA.
AD  - Department of Pediatrics, Washington University School of Medicine, St. Louis, 
      Missouri, USA.
FAU - Florence, Julaine
AU  - Florence J
AD  - Department of Neurology, Washington University School of Medicine, 660 South 
      Euclid Avenue, Box 8111, St. Louis, Missouri, 63110, USA.
FAU - Wong, Brenda L
AU  - Wong BL
AD  - Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 
      Cincinnati, Ohio, USA.
FAU - Parsons, Julie A
AU  - Parsons JA
AD  - Department of Pediatrics and Neurology, University of Colorado, Denver, Colorado, 
      USA.
FAU - Apkon, Susan
AU  - Apkon S
AD  - Department of Rehabilitation Medicine, University of Washington, Seattle, 
      Washington, USA.
FAU - Goyal, Namita
AU  - Goyal N
AD  - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, 
      USA.
FAU - Williams, Eugene
AU  - Williams E
AD  - DART Therapeutics, Inc, Stockbridge, Massachusetts, USA.
FAU - Escolar, Diana
AU  - Escolar D
AD  - DART Therapeutics, Inc, Stockbridge, Massachusetts, USA.
FAU - Rutkove, Seward B
AU  - Rutkove SB
AD  - Department of Neurology, Beth Israel Deaconess Medical Center, Boston, 
      Massachusetts, USA.
FAU - Bohorquez, Jose L
AU  - Bohorquez JL
AD  - Skulpt, Inc, Boston, Massachusetts, USA.
CN  - DART-EIM Clinical Evaluators Consortium
LA  - eng
GR  - R43NS073188/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150724
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - *Electric Impedance
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle Strength/*physiology
MH  - Muscle Strength Dynamometer
MH  - Muscle, Skeletal/*physiopathology
MH  - Muscular Dystrophy, Duchenne/*pathology/*physiopathology
MH  - Myography
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Duchenne muscular dystrophy
OT  - biomarker
OT  - children
OT  - electrical impedance myography
OT  - myopathy
FIR - Malkus, Betsy C
IR  - Malkus BC
FIR - Siener, Catherine
IR  - Siener C
FIR - Schierbecker, Jeanine R
IR  - Schierbecker JR
FIR - Stover, Lisa
IR  - Stover L
FIR - Morehart, Paula
IR  - Morehart P
FIR - Miller, Lauren
IR  - Miller L
FIR - Yang, Michele
IR  - Yang M
FIR - Carry, Terri
IR  - Carry T
FIR - Gibbons, Melissa
IR  - Gibbons M
FIR - Vogel, Leslie
IR  - Vogel L
FIR - Richardson, Randal
IR  - Richardson R
FIR - Townsend, Elise L
IR  - Townsend EL
EDAT- 2015/02/24 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/24 06:00
PHST- 2014/07/07 00:00 [received]
PHST- 2015/02/02 00:00 [revised]
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/02/24 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1002/mus.24611 [doi]
PST - ppublish
SO  - Muscle Nerve. 2015 Oct;52(4):592-7. doi: 10.1002/mus.24611. Epub 2015 Jul 24.