PMID- 25703003
OWN - NLM
STAT- MEDLINE
DCOM- 20151130
LR  - 20150223
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 136
DP  - 2015 May
TI  - Determination of eight pharmaceuticals in an aqueous sample using automated 
      derivatization solid-phase microextraction combined with gas chromatography-mass 
      spectrometry.
PG  - 198-203
LID - S0039-9140(15)00035-1 [pii]
LID - 10.1016/j.talanta.2014.11.071 [doi]
AB  - An automated aqueous derivatization solid-phase microextraction (SPME) coupled 
      with a gas chromatography/mass spectrometry (GC/MS) method was developed for 
      simultaneous determination of eight pharmaceuticals in water samples. Dimethyl 
      sulfate and tetrabutylammonium hydrogen sulfate were selected as derivatization 
      and activation reagents for the esterification reaction. An experimental design 
      approach, central composition design (CCD), was employed to investigate and 
      optimize the operative factors influencing the extraction efficiency, including 
      extraction time, extraction temperature and ionic strength. The other parameters 
      such as type of fiber coating, pH and derivatization conditions were also 
      evaluated. SPME was finally carried out in headspace mode at 80 degrees C for 60min with 
      the presence of 3.00g Na2SO4, using a home-made 44mum PDMS fiber. Wide linear 
      ranges and low limits of detection (0.06-1.24ng L(-1)) were obtained under the 
      optimized conditions. The relative standard deviations (RSDs) and recoveries 
      ranged from 0.5% to 12.3% and 85% to 110%, respectively. The proposed method was 
      successfully applied to the analysis of the real surface water samples from the 
      Pearl River Estuary.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Huang, Siming
AU  - Huang S
AD  - MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy 
      Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, 
      Guangzhou 510275, China.
FAU - Zhu, Fang
AU  - Zhu F
AD  - MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy 
      Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, 
      Guangzhou 510275, China.
FAU - Jiang, Ruifen
AU  - Jiang R
AD  - MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy 
      Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, 
      Guangzhou 510275, China.
FAU - Zhou, Shichun
AU  - Zhou S
AD  - MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy 
      Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, 
      Guangzhou 510275, China.
FAU - Zhu, Derong
AU  - Zhu D
AD  - Department of Pharmaceutical Analysis, Guangdong Medical College, Dongwan 523808, 
      Guangdong, China.
FAU - Liu, Hong
AU  - Liu H
AD  - MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy 
      Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, 
      Guangzhou 510275, China.
FAU - Ouyang, Gangfeng
AU  - Ouyang G
AD  - MOE Key Laboratory of Aquatic Product Safety/KLGHEI of Environment and Energy 
      Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, 
      Guangzhou 510275, China. Electronic address: cesoygf@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150123
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - China
MH  - Environmental Monitoring
MH  - Gas Chromatography-Mass Spectrometry
MH  - Pharmaceutical Preparations/*analysis
MH  - Seawater/*analysis
MH  - Solid Phase Microextraction
MH  - Water Pollutants, Chemical/*analysis
OTO - NOTNLM
OT  - Automation
OT  - Central composite design
OT  - Derivatization
OT  - Pharmaceutical
OT  - Solid-phase microextraction
OT  - The Pearl River Estuary
EDAT- 2015/02/24 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/24 06:00
PHST- 2014/09/10 00:00 [received]
PHST- 2014/10/25 00:00 [revised]
PHST- 2014/11/01 00:00 [accepted]
PHST- 2015/02/24 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0039-9140(15)00035-1 [pii]
AID - 10.1016/j.talanta.2014.11.071 [doi]
PST - ppublish
SO  - Talanta. 2015 May;136:198-203. doi: 10.1016/j.talanta.2014.11.071. Epub 2015 Jan 
      23.