PMID- 25703281
OWN - NLM
STAT- MEDLINE
DCOM- 20151207
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 108
IP  - 2
DP  - 2015 May
TI  - Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with 
      myocardial infarction in Slovene patients with type 2 diabetes mellitus.
PG  - 323-8
LID - S0168-8227(15)00078-9 [pii]
LID - 10.1016/j.diabres.2015.01.038 [doi]
AB  - OBJECTIVES: The aim of our study was to investigate the relationship between 
      genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and 
      myocardial infarction (MI) in subjects with type 2 diabetes mellitus (T2DM) of 
      Slovenian origin. METHODS: The study population consisted of 972 Caucasian 
      subjects with T2DM of more than 10 years' duration: 161 patients with MI and 811 
      patients with no history of coronary artery disease. Polymorphisms in thioredoxin 
      reductase 2 (TXNRD2) gene, rs1548357, rs4485648, and rs5748469, were studied. 
      RESULTS: Individuals carrying CC+CT genotypes of rs1548357 TXNRD2 polymorphism 
      had lower prevalence of MI compared with TT genotype group (41.6% vs 52.8%, 
      OR=0.589, 95% CI=0.368-0.942, P=0.027). CONCLUSIONS: The TXNRD2 rs 1548357 
      polymorphism might be a genetic risk factor for MI in subjects with T2DM of 
      Slovenian origin.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Kariz, Stojan
AU  - Kariz S
AD  - Internal Department, General Hospital Izola, Polje 35, 6310 Izola, Slovenia.
FAU - Mankoc, Sara
AU  - Mankoc S
AD  - Institute of Histology and Embryology, Faculty of Medicine, University Ljubljana, 
      Korytkova 2, 1105 Ljubljana, Slovenia.
FAU - Petrovic, Daniel
AU  - Petrovic D
AD  - Institute of Histology and Embryology, Faculty of Medicine, University Ljubljana, 
      Korytkova 2, 1105 Ljubljana, Slovenia. Electronic address: 
      daniel.petrovic@mf.uni-lj.si.
LA  - eng
PT  - Journal Article
DEP - 20150207
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - EC 1.8.1.9 (TXNRD2 protein, human)
RN  - EC 1.8.1.9 (Thioredoxin Reductase 2)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Diabetic Angiopathies/epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Slovenia/epidemiology
MH  - Thioredoxin Reductase 2/*genetics
MH  - White People/genetics
OTO - NOTNLM
OT  - Genetic polymorphisms
OT  - Myocardial infarction
OT  - Oxidative stress
OT  - Thioredoxin reductase 2
OT  - Type 2 diabetes mellitus
EDAT- 2015/02/24 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/24 06:00
PHST- 2014/07/29 00:00 [received]
PHST- 2014/12/28 00:00 [revised]
PHST- 2015/01/30 00:00 [accepted]
PHST- 2015/02/24 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0168-8227(15)00078-9 [pii]
AID - 10.1016/j.diabres.2015.01.038 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2015 May;108(2):323-8. doi: 
      10.1016/j.diabres.2015.01.038. Epub 2015 Feb 7.