PMID- 25703477
OWN - NLM
STAT- MEDLINE
DCOM- 20150626
LR  - 20151025
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 159
IP  - 5
DP  - 2015 May
TI  - The association between glaucoma and immunoglobulin E antibody response to indoor 
      allergens.
PG  - 986-93.e1
LID - S0002-9394(15)00093-8 [pii]
LID - 10.1016/j.ajo.2015.02.007 [doi]
AB  - PURPOSE: To evaluate the association between sensitization to indoor allergens 
      and glaucoma in participants of the National Health and Nutrition Examination 
      Survey (NHANES). DESIGN: Retrospective cross-sectional study. METHODS: This study 
      examined the association between serum immunoglobulin E (IgE) levels for a panel 
      of common indoor allergens and glaucoma for 2005-2006 NHANES participants. The 
      exposures of interest were serum IgE levels to a panel of common indoor 
      allergens. The outcome of interest was a clinical diagnosis of glaucoma based on 
      the Rotterdam criteria. Logistic regression modeling was performed to assess the 
      association between each type of IgE and glaucoma, while controlling for age, 
      ethnicity, and steroid use. All estimates were weighted based on the multistage 
      NHANES sampling design. RESULTS: Among a weighted total of 83 308 318 
      participants, the overall prevalence of glaucoma was 3.2% (95% confidence 
      interval [CI]: 2.8%, 3.6%). The majority of patients were non-Hispanic white (n = 
      10 547 654; 77.1%). The American dust mite antigen had the highest proportion of 
      participants with positive IgE values (n = 12 093 038; 14.5%). In the full model 
      including all allergen-specific IgE subtypes as predictors, there were 
      statistically significant associations between IgE subtypes and glaucoma for the 
      cockroach (odds ratio [OR] = 2.78; 95% CI = 1.34, 5.76), cat (OR = 3.42; 95% 
      CI = 1.10, 10.67), and dog (OR = 0.24; 95% CI = 0.06, 0.96) antigens. 
      CONCLUSIONS: In NHANES, participants with glaucoma had significantly higher odds 
      of sensitization to the cockroach and cat allergens compared to those without 
      glaucoma. These findings indicate the need for further research to elucidate the 
      role of chronic indoor allergen exposure in the development of glaucomatous optic 
      neuropathy.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Tseng, Victoria L
AU  - Tseng VL
AD  - Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, 
      California; Department of Epidemiology, UCLA Fielding School of Public Health, 
      Los Angeles, California.
FAU - Lee, Gina Y
AU  - Lee GY
AD  - Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, 
      California.
FAU - Shaikh, Yahya
AU  - Shaikh Y
AD  - Department of Preventive Medicine, Johns Hopkins University Bloomberg School of 
      Public Health, Baltimore, Maryland.
FAU - Yu, Fei
AU  - Yu F
AD  - Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, 
      California; Department of Biostatistics, UCLA Fielding School of Public Health, 
      Los Angeles, California.
FAU - Coleman, Anne L
AU  - Coleman AL
AD  - Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, 
      California; Department of Epidemiology, UCLA Fielding School of Public Health, 
      Los Angeles, California. Electronic address: coleman@jsei.ucla.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150219
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
RN  - 0 (Air Pollutants)
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Am J Ophthalmol. 2015 Sep;160(3):614. PMID: 26116194
CIN - Br J Ophthalmol. 2015 Aug;99(8):1015-6. PMID: 26130672
CIN - Am J Ophthalmol. 2015 Sep;160(3):614-5. PMID: 26283283
MH  - Adult
MH  - Aged
MH  - Air Pollutants/*immunology
MH  - *Air Pollution, Indoor
MH  - Allergens/*immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma, Open-Angle/diagnosis/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Optic Nerve Diseases/diagnosis/*immunology
MH  - Retrospective Studies
MH  - Visual Fields
EDAT- 2015/02/24 06:00
MHDA- 2015/06/27 06:00
CRDT- 2015/02/24 06:00
PHST- 2014/11/07 00:00 [received]
PHST- 2015/02/15 00:00 [revised]
PHST- 2015/02/17 00:00 [accepted]
PHST- 2015/02/24 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2015/06/27 06:00 [medline]
AID - S0002-9394(15)00093-8 [pii]
AID - 10.1016/j.ajo.2015.02.007 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2015 May;159(5):986-93.e1. doi: 10.1016/j.ajo.2015.02.007. Epub 
      2015 Feb 19.