PMID- 25705093
OWN - NLM
STAT- MEDLINE
DCOM- 20160111
LR  - 20230513
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2015
DP  - 2015
TI  - Role of the immunogenic and tolerogenic subsets of dendritic cells in multiple 
      sclerosis.
PG  - 513295
LID - 10.1155/2015/513295 [doi]
LID - 513295
AB  - Multiple sclerosis (MS) is an immune-mediated disorder in the central nervous 
      system (CNS) characterized by inflammation and demyelination as well as axonal 
      and neuronal degeneration. So far effective therapies to reverse the disease are 
      still lacking; most therapeutic drugs can only ameliorate the symptoms or reduce 
      the frequency of relapse. Dendritic cells (DCs) are professional antigen 
      presenting cells (APCs) that are key players in both mediating immune responses 
      and inducing immune tolerance. Increasing evidence indicates that DCs contribute 
      to the pathogenesis of MS and might provide an avenue for therapeutic 
      intervention. Here, we summarize the immunogenic and tolerogenic roles of DCs in 
      MS and review medicinal drugs that may affect functions of DCs and have been 
      applied in clinic for MS treatment. We also describe potential therapeutic 
      molecules that can target DCs by inducing anti-inflammatory cytokines and 
      inhibiting proinflammatory cytokines in MS.
FAU - Xie, Zhong-Xiang
AU  - Xie ZX
AD  - Neuroscience Center, Department of Neurology, The First Hospital of Jilin 
      University, Changchun 130021, China.
FAU - Zhang, Hong-Liang
AU  - Zhang HL
AD  - Neuroscience Center, Department of Neurology, The First Hospital of Jilin 
      University, Changchun 130021, China ; Department of Neurobiology, Care Sciences 
      and Society, Karolinska Institute, 141 86 Stockholm, Sweden.
FAU - Wu, Xiu-Juan
AU  - Wu XJ
AD  - Neuroscience Center, Department of Neurology, The First Hospital of Jilin 
      University, Changchun 130021, China.
FAU - Zhu, Jie
AU  - Zhu J
AD  - Neuroscience Center, Department of Neurology, The First Hospital of Jilin 
      University, Changchun 130021, China ; Department of Neurobiology, Care Sciences 
      and Society, Karolinska Institute, 141 86 Stockholm, Sweden.
FAU - Ma, Di-Hui
AU  - Ma DH
AD  - Neuroscience Center, Department of Neurology, The First Hospital of Jilin 
      University, Changchun 130021, China.
FAU - Jin, Tao
AU  - Jin T
AD  - Neuroscience Center, Department of Neurology, The First Hospital of Jilin 
      University, Changchun 130021, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150129
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/immunology
MH  - Central Nervous System/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Multiple Sclerosis/*immunology
PMC - PMC4325219
EDAT- 2015/02/24 06:00
MHDA- 2016/01/12 06:00
PMCR- 2015/01/29
CRDT- 2015/02/24 06:00
PHST- 2014/08/24 00:00 [received]
PHST- 2015/01/01 00:00 [revised]
PHST- 2015/01/01 00:00 [accepted]
PHST- 2015/02/24 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2016/01/12 06:00 [medline]
PHST- 2015/01/29 00:00 [pmc-release]
AID - 10.1155/2015/513295 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2015;2015:513295. doi: 10.1155/2015/513295. Epub 2015 Jan 29.