PMID- 25706090
OWN - NLM
STAT- MEDLINE
DCOM- 20160307
LR  - 20220408
IS  - 1651-2316 (Electronic)
IS  - 1650-6073 (Print)
IS  - 1650-6073 (Linking)
VI  - 44
IP  - 4
DP  - 2015
TI  - Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy 
      Data.
PG  - 314-27
LID - 10.1080/16506073.2015.1012740 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is associated with synaptic plasticity, 
      which is crucial for long-term learning and memory. Some studies suggest that 
      people suffering from anxiety disorders show reduced BDNF relative to healthy 
      controls. Lower BDNF is associated with impaired learning, cognitive deficits, 
      and poor exposure-based treatment outcomes. A series of studies with rats showed 
      that exercise elevates BDNF and enhances fear extinction. However, this strategy 
      has not been tested in humans. In this pilot study, we randomized participants (N 
      = 9, 8 females, M(Age) = 34) with posttraumatic stress disorder (PTSD) to (a) 
      prolonged exposure alone (PE) or (b) prolonged exposure+exercise (PE+E). 
      Participants randomized to the PE+E condition completed a 30-minute bout of 
      moderate-intensity treadmill exercise (70% of age-predicted HR(max)) prior to 
      each PE session. Consistent with prediction, the PE+E group showed a greater 
      improvement in PTSD symptoms (d = 2.65) and elevated BDNF (d = 1.08) relative to 
      the PE only condition. This pilot study provides initial support for further 
      investigation into exercise augmented exposure therapy.
FAU - Powers, Mark B
AU  - Powers MB
AD  - a Department of Psychology, Institute for Mental Health Research , The University 
      of Texas at Austin , Austin , TX , USA.
FAU - Medina, Johnna L
AU  - Medina JL
FAU - Burns, Stephanie
AU  - Burns S
FAU - Kauffman, Brooke Y
AU  - Kauffman BY
FAU - Monfils, Marie
AU  - Monfils M
FAU - Asmundson, Gordon J G
AU  - Asmundson GJ
FAU - Diamond, Allison
AU  - Diamond A
FAU - McIntyre, Christa
AU  - McIntyre C
FAU - Smits, Jasper A J
AU  - Smits JA
LA  - eng
SI  - ClinicalTrials.gov/NCT01199107
GR  - F31 DA036919/DA/NIDA NIH HHS/United States
GR  - R01 MH091147/MH/NIMH NIH HHS/United States
GR  - R01 DA027533/DA/NIDA NIH HHS/United States
GR  - K01 DA035930/DA/NIDA NIH HHS/United States
GR  - R15 MH099655/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20150223
PL  - England
TA  - Cogn Behav Ther
JT  - Cognitive behaviour therapy
JID - 101143317
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Combined Modality Therapy/methods
MH  - Exercise/*psychology
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Implosive Therapy/*methods
MH  - Male
MH  - Pilot Projects
MH  - Stress Disorders, Post-Traumatic/blood/*therapy
MH  - Young Adult
PMC - PMC4464974
MID - NIHMS682582
OTO - NOTNLM
OT  - BDNF
OT  - CBT
OT  - anxiety disorders
OT  - augmentation
OT  - exercise
OT  - exposure therapy
OT  - pilot data
EDAT- 2015/02/24 06:00
MHDA- 2016/03/08 06:00
PMCR- 2016/06/01
CRDT- 2015/02/24 06:00
PHST- 2015/02/24 06:00 [entrez]
PHST- 2015/02/24 06:00 [pubmed]
PHST- 2016/03/08 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - 10.1080/16506073.2015.1012740 [doi]
PST - ppublish
SO  - Cogn Behav Ther. 2015;44(4):314-27. doi: 10.1080/16506073.2015.1012740. Epub 2015 
      Feb 23.