PMID- 2570704
OWN - NLM
STAT- MEDLINE
DCOM- 19891018
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 165
IP  - 2-3
DP  - 1989 Jun 20
TI  - Effect of MK-801 on the decrease in tryptophan hydroxylase induced by 
      methamphetamine and its methylenedioxy analog.
PG  - 315-8
AB  - The role of N-methyl-D-aspartate (NMDA) receptors in the decrease in neostriatal 
      tryptophan hydroxylase (TPH) activity induced by repeated high doses of 
      methamphetamine or 3,4-methylenedioxymethamphetamine (MDMA) was evaluated. Rats 
      received 4 injections of methamphetamine (15 mg/kg) or MDMA (10 mg/kg) at 6 h 
      intervals, and were killed 18-20 h after the last administration. These 
      treatments with methamphetamine or MDMA reduced neostriatal TPH activity to 26 
      and 34% of control, respectively. Coadministration of MK-801 (2.5 mg/kg) 
      significantly attenuated the methamphetamine-induced decrease in TPH activity 
      (66% of control), but did not alter the effect of MDMA. This study suggests that 
      excitatory amino acids may participate in the methamphetamine-induced decline in 
      central TPH activity, and that the mechanism by which MDMA and methamphetamine 
      decreases TPH activity may differ.
FAU - Johnson, M
AU  - Johnson M
AD  - Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 
      84112.
FAU - Hanson, G R
AU  - Hanson GR
FAU - Gibb, J W
AU  - Gibb JW
LA  - eng
GR  - DA 00869/DA/NIDA NIH HHS/United States
GR  - DA 04221/DA/NIDA NIH HHS/United States
GR  - MH 44454/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amphetamines)
RN  - 0 (Anticonvulsants)
RN  - 0 (Dibenzocycloheptenes)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Anticonvulsants/*pharmacology
MH  - Dibenzocycloheptenes/*pharmacology
MH  - Dizocilpine Maleate
MH  - Male
MH  - Methamphetamine/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, N-Methyl-D-Aspartate
MH  - Receptors, Neurotransmitter/metabolism
MH  - Tryptophan Hydroxylase/antagonists & inhibitors/*metabolism
EDAT- 1989/06/20 00:00
MHDA- 1989/06/20 00:01
CRDT- 1989/06/20 00:00
PHST- 1989/06/20 00:00 [pubmed]
PHST- 1989/06/20 00:01 [medline]
PHST- 1989/06/20 00:00 [entrez]
AID - 0014-2999(89)90728-0 [pii]
AID - 10.1016/0014-2999(89)90728-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1989 Jun 20;165(2-3):315-8. doi: 10.1016/0014-2999(89)90728-0.