PMID- 25708464
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20160518
IS  - 1937-6448 (Print)
IS  - 1937-6448 (Linking)
VI  - 315
DP  - 2015
TI  - Nuclear compartments, genome folding, and enhancer-promoter communication.
PG  - 183-244
LID - S1937-6448(14)00012-4 [pii]
LID - 10.1016/bs.ircmb.2014.11.004 [doi]
AB  - The eukaryotic genome has an extremely complex spatial organization. The physical 
      distances between regulatory elements of the genome, such as enhancers, 
      promoters, insulators, and CpG-islands, do not necessarily reflect genomic 
      distances. Some remote regulatory elements appear to interact physically with 
      target promoters in the 3D nuclear space. These spatial contacts are thought to 
      play a crucial role in the regulation of transcription. Recent studies performed 
      using 3C (chromosome conformation capture)-based methods, FISH (fluorescence in 
      situ hybridization) coupled with confocal microscopy, and other experimental 
      approaches have revealed that the spatial interactions of distant genomic 
      elements within a folded chromosome are specific and functionally relevant. 
      Additionally, the spatial organization of the eukaryotic genome is linked to the 
      functional compartmentalization of the cell nucleus. In this review, we discuss 
      the current state of research on the functional architecture of the eukaryotic 
      genome. Special emphasis is given to the role of the spatial organization of the 
      genome in establishing communication between enhancers and promoters. The driving 
      forces of the juxtaposition of remote genomic elements are also considered.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Ulianov, Sergey V
AU  - Ulianov SV
AD  - Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia; Lomonosov 
      Moscow State University, Moscow, Russia.
FAU - Gavrilov, Alexey A
AU  - Gavrilov AA
AD  - Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
FAU - Razin, Sergey V
AU  - Razin SV
AD  - Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia; Lomonosov 
      Moscow State University, Moscow, Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150209
PL  - Netherlands
TA  - Int Rev Cell Mol Biol
JT  - International review of cell and molecular biology
JID - 101475846
RN  - 0 (Chromatin)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/*metabolism
MH  - Chromatin/metabolism
MH  - Enhancer Elements, Genetic/*genetics
MH  - *Genome
MH  - Humans
MH  - Nucleic Acid Conformation
MH  - Promoter Regions, Genetic/*genetics
OTO - NOTNLM
OT  - 3D genome organization
OT  - Active chromatin hub
OT  - Chromatin
OT  - Enhancer-promoter communication
OT  - HiC
OT  - Nuclear compartment
EDAT- 2015/02/25 06:00
MHDA- 2015/11/17 06:00
CRDT- 2015/02/25 06:00
PHST- 2015/02/25 06:00 [entrez]
PHST- 2015/02/25 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - S1937-6448(14)00012-4 [pii]
AID - 10.1016/bs.ircmb.2014.11.004 [doi]
PST - ppublish
SO  - Int Rev Cell Mol Biol. 2015;315:183-244. doi: 10.1016/bs.ircmb.2014.11.004. Epub 
      2015 Feb 9.