PMID- 25708564
OWN - NLM
STAT- MEDLINE
DCOM- 20150918
LR  - 20221207
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 31
IP  - 4
DP  - 2015 Apr
TI  - Six-minute walk test in Chinese adults with clinically stable bronchiectasis: 
      association with clinical indices and determinants.
PG  - 843-52
LID - 10.1185/03007995.2015.1013625 [doi]
AB  - BACKGROUND: The profiles of 6-minute walk distance (6MWD) in adults with 
      clinically stable bronchiectasis in Chinese adult patients with bronchiectasis 
      are unclear. OBJECTIVES: To delineate the 6MWD by stratification of clinical 
      indices, and to investigate the factors associated with reduced 6MWD in Chinese 
      adults with clinically stable bronchiectasis. METHODS: We recruited 141 adult 
      bronchiectasis patients (mean age: 44.3 +/- 13.9 years). Demography, radiology, 
      spirometry, diffusing capacity, etiology, sputum bacteriology, modified Medical 
      Research Council dyspnea scale (MMRC) and quality of life were assessed. The 
      safety profile of the measurement was also examined. RESULTS: Lower levels of 
      6MWD were associated with older age (>50 years), higher HRCT total score, 
      presence of cystic bronchiectasis, bilateral bronchiectasis, reduced diffusing 
      capacity, higher MMRC score, and higher SGRQ scores. Correlation coefficients 
      between 6MWD and spirometry and quality of life scores were different in patients 
      with 6MWD higher and lower than lower limit of normal. DLCO being less than 80% 
      predicted (OR = 3.13, 95% CI: 1.32-7.43, P = 0.01) and MMRC scale between 1 and 4 
      (OR = 6.42, 95% CI: 2.27-18.18, P < 0.01) were the factors associated with 6MWD 
      being less than the lower limit of normal (80% predicted value). No severe 
      adverse events were reported. CONCLUSION: The 6MWD could be safely measured in 
      adult patients with bronchiectasis and is poorly associated with clinical 
      parameters. DLCO less than 80% predicted and higher MMRC scale are independent 
      predictors of 6MWD below the lower limit of normal. Our findings will provide a 
      reference for management of bronchiectasis patients in mainland China.
FAU - Guan, Wei-Jie
AU  - Guan WJ
AD  - State Key Laboratory of Respiratory Disease, National Clinical Research Center 
      for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First 
      Affiliated Hospital of Guangzhou Medical University , Guangzhou, Guangdong , 
      China.
FAU - Gao, Yong-Hua
AU  - Gao YH
FAU - Xu, Gang
AU  - Xu G
FAU - Lin, Zhi-Ya
AU  - Lin ZY
FAU - Tang, Yan
AU  - Tang Y
FAU - Li, Hui-Min
AU  - Li HM
FAU - Lin, Zhi-Min
AU  - Lin ZM
FAU - Zheng, Jin-Ping
AU  - Zheng JP
FAU - Chen, Rong-Chang
AU  - Chen RC
FAU - Zhong, Nan-Shan
AU  - Zhong NS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150303
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Bronchiectasis/*physiopathology
MH  - China
MH  - Cross-Sectional Studies
MH  - Exercise Test/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Spirometry
MH  - Walking/*physiology
OTO - NOTNLM
OT  - Bacteriology
OT  - Bronchiectasis
OT  - Etiology
OT  - Quality of life
OT  - Radiology
OT  - Six-minute walk test
EDAT- 2015/02/25 06:00
MHDA- 2015/09/19 06:00
CRDT- 2015/02/25 06:00
PHST- 2015/02/25 06:00 [entrez]
PHST- 2015/02/25 06:00 [pubmed]
PHST- 2015/09/19 06:00 [medline]
AID - 10.1185/03007995.2015.1013625 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2015 Apr;31(4):843-52. doi: 10.1185/03007995.2015.1013625. 
      Epub 2015 Mar 3.