PMID- 25709101
OWN - NLM
STAT- MEDLINE
DCOM- 20160128
LR  - 20181113
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 49
IP  - 3
DP  - 2015 May
TI  - Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early 
      binge-like prenatal alcohol exposure in mice.
PG  - 207-17
LID - S0741-8329(14)20219-9 [pii]
LID - 10.1016/j.alcohol.2015.01.005 [doi]
AB  - The range of defects that fall within fetal alcohol spectrum disorder (FASD) 
      includes persistent behavioral problems, with anxiety and depression being two of 
      the more commonly reported issues. Previous studies of rodent FASD models suggest 
      that interference with hypothalamic-pituitary-adrenal (HPA) axis structure and/or 
      function may be the basis for some of the prenatal alcohol (ethanol) exposure 
      (PAE)-induced behavioral abnormalities. Included among the previous 
      investigations are those illustrating that maternal alcohol treatment limited to 
      very early stages of pregnancy (i.e., gestational day [GD]7 in mice; equivalent 
      to the third week post-fertilization in humans) can cause structural 
      abnormalities in areas such as the hypothalamus, pituitary gland, and other 
      forebrain regions integral to controlling stress and behavioral responses. The 
      current investigation was designed to further examine the sequelae of prenatal 
      alcohol insult at this early time period, with particular attention to HPA 
      axis-associated functional changes in adult mice. The results of this study 
      reveal that GD7 PAE in mice causes HPA axis dysfunction, with males and females 
      showing elevated corticosterone (CORT) and adrenocorticotropic hormone (ACTH) 
      levels, respectively, following a 15-min restraint stress exposure. Males also 
      showed elevated CORT levels following an acute alcohol injection of 2.0 g/kg, 
      while females displayed blunted ACTH levels. Furthermore, analysis showed that 
      anxiety-like behavior was decreased after GD7 PAE in female mice, but was 
      increased in male mice. Collectively, the results of this study show that early 
      gestational alcohol exposure in mice alters long-term HPA axis activity and 
      behavior in a sexually dimorphic manner.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Wieczorek, Lindsay
AU  - Wieczorek L
AD  - Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, 
      USA. Electronic address: lawieczo@med.unc.edu.
FAU - Fish, Eric W
AU  - Fish EW
AD  - Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, 
      USA.
FAU - O'Leary-Moore, Shonagh K
AU  - O'Leary-Moore SK
AD  - Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, 
      USA; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, 
      USA.
FAU - Parnell, Scott E
AU  - Parnell SE
AD  - Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, 
      USA; Carolina Institute for Developmental Disabilities, University of North 
      Carolina, Chapel Hill, NC, USA; Department of Cell Biology and Physiology, 
      University of North Carolina, Chapel Hill, NC, USA.
FAU - Sulik, Kathleen K
AU  - Sulik KK
AD  - Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC, 
      USA; Carolina Institute for Developmental Disabilities, University of North 
      Carolina, Chapel Hill, NC, USA; Department of Cell Biology and Physiology, 
      University of North Carolina, Chapel Hill, NC, USA.
LA  - eng
GR  - AA007573/AA/NIAAA NIH HHS/United States
GR  - AA021651/AA/NIAAA NIH HHS/United States
GR  - P60 AA011605/AA/NIAAA NIH HHS/United States
GR  - AA011605/AA/NIAAA NIH HHS/United States
GR  - P50 AA011605/AA/NIAAA NIH HHS/United States
GR  - T32 AA007573/AA/NIAAA NIH HHS/United States
GR  - U01 AA021651/AA/NIAAA NIH HHS/United States
GR  - U54 HD079124/HD/NICHD NIH HHS/United States
GR  - U54HD079124/HD/NICHD NIH HHS/United States
GR  - R00 AA018697/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150126
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/*drug effects/metabolism
MH  - Animals
MH  - Anxiety/metabolism/psychology
MH  - Behavior, Animal/*drug effects
MH  - Binge Drinking
MH  - Central Nervous System Depressants/*pharmacology
MH  - Corticosterone/*metabolism
MH  - Depression/metabolism/psychology
MH  - Disease Models, Animal
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/metabolism/psychology
MH  - Hypothalamo-Hypophyseal System/*drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Pituitary-Adrenal System/*drug effects/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/metabolism/psychology
MH  - Restraint, Physical
MH  - Sex Factors
MH  - Stress, Psychological/metabolism/psychology
PMC - PMC4414725
MID - NIHMS658643
OTO - NOTNLM
OT  - Anxiety
OT  - Depression
OT  - FASD
OT  - Hypothalamic-pituitary-adrenal axis
OT  - Prenatal alcohol exposure
OT  - Stress
COIS- The authors have no financial or other conflicts of interest.
EDAT- 2015/02/25 06:00
MHDA- 2016/01/29 06:00
PMCR- 2016/05/01
CRDT- 2015/02/25 06:00
PHST- 2014/11/11 00:00 [received]
PHST- 2015/01/13 00:00 [revised]
PHST- 2015/01/14 00:00 [accepted]
PHST- 2015/02/25 06:00 [entrez]
PHST- 2015/02/25 06:00 [pubmed]
PHST- 2016/01/29 06:00 [medline]
PHST- 2016/05/01 00:00 [pmc-release]
AID - S0741-8329(14)20219-9 [pii]
AID - 10.1016/j.alcohol.2015.01.005 [doi]
PST - ppublish
SO  - Alcohol. 2015 May;49(3):207-17. doi: 10.1016/j.alcohol.2015.01.005. Epub 2015 Jan 
      26.