PMID- 25709792
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150224
LR  - 20220408
IS  - 2008-7802 (Print)
IS  - 2008-8213 (Electronic)
IS  - 2008-7802 (Linking)
VI  - 5
IP  - 12
DP  - 2014 Dec
TI  - Effect of conjugated linoleic Acid, vitamin e, alone or combined on immunity and 
      inflammatory parameters in adults with active rheumatoid arthritis: a randomized 
      controlled trial.
PG  - 1567-77
AB  - BACKGROUND: Little information about the effects of conjugated linoleic acids 
      (CLAs) on inflammation and immune function in humans is available. This study 
      investigated the effects of CLAs, with and without Vitamin E on immunity and 
      inflammatory parameters in adults with active rheumatoid arthritis (RA). METHODS: 
      In a double-blind clinical trial, 78 patients were randomly divided into four 
      groups, each group receiving one of the following daily supplement for 3 months; 
      group C: 2.5 g CLAs, group E: 400 mg Vitamin E, group CE: CLAs plus Vitamin E, 
      group P: Placebo. Cytokines, matrix metalloproteinase 3 (MMP-3) and citrullinated 
      antibody (CCP-A) were measured by ELISA method and Vitamin E by high-performance 
      liquid chromatography. RESULTS: Consider statistical methods there were no 
      significant differences between groups in cytokines interleukin-2 (IL-2), IL-4, 
      tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-2/IL-4, CCP-A white blood cells and 
      neutrophils, lymphocyte, monocytes, and eosinophils numbers. TNF-alpha decreased in 
      all groups, but its reduction was significant in group CE. IL-1beta increased in 
      groups P (P = 0.004) and E (P = 0.041) but the difference between group P and CE 
      was significant. IL-4 decreased in groups C, CE and E (P = 0.03, P = 0.03, P = 
      0.07 respectively). IL2 did not change significantly within groups. CCP-A 
      increased in groups P (P = 0.035) and E (P = 0.05), while it decreased in groups 
      CE (P = 0.034). CCP-A and MMP-3 decrease were significant between groups P and 
      CE. MMP-3 reduction was significant in group CE. CONCLUSIONS: Co-supplementation 
      CLAs and Vitamin E may be effective in the level of inflammatory markers in RA 
      patients.
FAU - Aryaeian, Naheed
AU  - Aryaeian N
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Djalali, Mahmoud
AU  - Djalali M
AD  - Department of Cellular and Molecular Nutrition, School of Nutrition and 
      Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Shahram, Farhad
AU  - Shahram F
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Djazayery, Abolghassem
AU  - Djazayery A
AD  - Department of Public Nutrition, School of Nutrition and Dietetics, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Eshragian, Mohammad Reza
AU  - Eshragian MR
AD  - Department of Biostatistics and Epidemiology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Int J Prev Med
JT  - International journal of preventive medicine
JID - 101535380
PMC - PMC4336987
OTO - NOTNLM
OT  - Conjugated linoleic acids
OT  - Vitamin E
OT  - immunity
OT  - inflammatory markers
OT  - rheumatoid arthritis
COIS- Conflict of Interest: None declared.
EDAT- 2015/02/25 06:00
MHDA- 2015/02/25 06:01
PMCR- 2014/12/01
CRDT- 2015/02/25 06:00
PHST- 2013/09/25 00:00 [received]
PHST- 2014/10/21 00:00 [accepted]
PHST- 2015/02/25 06:00 [entrez]
PHST- 2015/02/25 06:00 [pubmed]
PHST- 2015/02/25 06:01 [medline]
PHST- 2014/12/01 00:00 [pmc-release]
AID - IJPVM-5-1567 [pii]
PST - ppublish
SO  - Int J Prev Med. 2014 Dec;5(12):1567-77.