PMID- 25709847
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150224
LR  - 20201001
IS  - 2090-6706 (Print)
IS  - 2090-6714 (Electronic)
VI  - 2015
DP  - 2015
TI  - A peculiar case of the abscopal effect: radioactive iodine therapy incidentally 
      palliating marginal zone lymphoma.
PG  - 281729
LID - 10.1155/2015/281729 [doi]
LID - 281729
AB  - The abscopal effect is an extremely rare phenomenon occurring when irradiation or 
      treatment of a primary tumor burden not only results in debulking of the targeted 
      site but also reduces tumor size at distant sites from the intended treatment 
      area. We present the abscopal effect occurring in a patient with low-grade 
      marginal zone lymphoma who subsequently received radioactive iodine therapy for 
      papillary thyroid carcinoma. She was 67 years old when a routine complete blood 
      count at her primary care physician's office yielded a persistent leukocytosis of 
      14,500/muL with lymphocytosis of 9,870/muL. Immunophenotyping and fluorescence in 
      situ hybridization (FISH) analysis confirmed low-grade marginal zone lymphoma. 
      Over eight years, her peak leukocyte and lymphocyte counts were 24,100/muL and 
      18,100/muL, respectively. Subsequently, she was diagnosed with papillary thyroid 
      carcinoma after presenting with a new complaint of dysphagia. A total 
      thyroidectomy was performed, followed by 172.1 millicuries of oral I-131 sodium 
      iodine radioactive ablation therapy. Following treatment, her leukocyte and 
      lymphocyte counts were 3,100/muL and 1,100/muL, respectively. Over the next four 
      years, her leukocyte and lymphocyte counts remained within normal limits and she 
      remained symptom free. To our knowledge, there has never been a published report 
      describing the use of radioactive iodine causing abscopal effect benefits for 
      patients with underlying lymphoproliferative diseases.
FAU - Kornas, Robert C
AU  - Kornas RC
AD  - Providence Hospital and Medical Centers, 16001 W. Nine Mile Road, Suite 401, 
      Southfield, MI 48075, USA.
FAU - Shields, Sarah-Kim
AU  - Shields SK
AD  - St. Joseph Mercy Oakland Hospital, 44405 Woodward Avenue, Pontiac, MI 48341, USA.
FAU - Goldman, Lyle S
AU  - Goldman LS
AD  - Providence Hospital and Medical Centers, 16001 W. Nine Mile Road, Suite 401, 
      Southfield, MI 48075, USA.
LA  - eng
PT  - Journal Article
DEP - 20150202
PL  - United States
TA  - Case Rep Oncol Med
JT  - Case reports in oncological medicine
JID - 101581035
PMC - PMC4332459
EDAT- 2015/02/25 06:00
MHDA- 2015/02/25 06:01
PMCR- 2015/02/02
CRDT- 2015/02/25 06:00
PHST- 2014/11/18 00:00 [received]
PHST- 2015/01/09 00:00 [accepted]
PHST- 2015/02/25 06:00 [entrez]
PHST- 2015/02/25 06:00 [pubmed]
PHST- 2015/02/25 06:01 [medline]
PHST- 2015/02/02 00:00 [pmc-release]
AID - 10.1155/2015/281729 [doi]
PST - ppublish
SO  - Case Rep Oncol Med. 2015;2015:281729. doi: 10.1155/2015/281729. Epub 2015 Feb 2.