PMID- 25710846 OWN - NLM STAT- MEDLINE DCOM- 20150917 LR - 20180816 IS - 1473-5873 (Electronic) IS - 0955-8829 (Linking) VI - 25 IP - 2 DP - 2015 Apr TI - Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder. PG - 95-6 LID - 10.1097/YPG.0000000000000077 [doi] AB - Obsessive-compulsive disorder (OCD) is a severe psychiatric condition with a clear genetic component (Nicolini et al., 2009) in which neurodevelopmental mechanisms may be etiologically important. Brain-derived neurotrophic factor (BDNF) is an interesting candidate for molecular analysis in OCD on the basis of potential functional relevance, positive association studies, and reported interaction between this gene and other neurotransmitters implicated in this disorder. FAU - Zai, Gwyneth AU - Zai G AD - aNeurogenetics Section, Centre for Addiction and Mental Health bDepartment of Psychiatry and Institute of Medical Science, University of Toronto cDepartment of Psychiatry and Program in Genetics and Genome Biology, Hospital for Sick Children dFrederick W. Thompson Anxiety Disorders Centre and Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. FAU - Zai, Clement C AU - Zai CC FAU - Arnold, Paul D AU - Arnold PD FAU - Freeman, Natalie AU - Freeman N FAU - Burroughs, Eliza AU - Burroughs E FAU - Kennedy, James L AU - Kennedy JL FAU - Richter, Margaret A AU - Richter MA LA - eng GR - Canadian Institutes of Health Research/Canada PT - Letter PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PL - England TA - Psychiatr Genet JT - Psychiatric genetics JID - 9106748 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Brain-Derived Neurotrophic Factor/*genetics MH - Genetic Association Studies MH - Genetic Predisposition to Disease MH - Humans MH - Obsessive-Compulsive Disorder/*genetics MH - Polymorphism, Single Nucleotide EDAT- 2015/02/25 06:00 MHDA- 2015/09/18 06:00 CRDT- 2015/02/25 06:00 PHST- 2015/02/25 06:00 [entrez] PHST- 2015/02/25 06:00 [pubmed] PHST- 2015/09/18 06:00 [medline] AID - 00041444-201504000-00006 [pii] AID - 10.1097/YPG.0000000000000077 [doi] PST - ppublish SO - Psychiatr Genet. 2015 Apr;25(2):95-6. doi: 10.1097/YPG.0000000000000077.