PMID- 25711508
OWN - NLM
STAT- MEDLINE
DCOM- 20171128
LR  - 20171128
IS  - 1935-1232 (Print)
IS  - 1935-1232 (Linking)
VI  - 11
IP  - 3
DP  - 2017 Fall
TI  - Disorganized Symptoms Predicted Worse Functioning Outcome in Schizophrenia 
      Patients with Established Illness.
PG  - 151-155
LID - 10.3371/CSRP.ORGA.022015 [doi]
AB  - Most patients with schizophrenia will have subsequent relapses of the disorder, 
      with continuous impairments in functioning. However, evidence is lacking on how 
      symptoms influence functioning at different phases of the disease. This study 
      aims to investigate the relationship between symptom dimensions and functioning 
      at different phases: acute exacerbation, nonremission and remission. METHODS: 
      Patients with schizophrenia were grouped into acutely ill (n=89), not remitted 
      (n=89), and remitted (n=69). Three exploratory stepwise linear regression 
      analyses were performed for each phase of schizophrenia, in which the five PANSS 
      factors and demographic variables were entered as the independent variables and 
      the total Global Assessment of Functioning Scale (GAF) score was entered as the 
      dependent variable. An additional exploratory stepwise logistic regression 
      analysis was performed to predict subsequent remission at discharge in the 
      inpatient population. RESULTS: The Disorganized factor was the most significant 
      predictor for acutely ill patients (p<0.001), while the Hostility factor was the 
      most significant for not-remitted patients and the Negative factor was the most 
      significant for remitted patients (p=0.001 and p<0.001, respectively). In the 
      logistic regression, the Disorganized factor score presented a significant 
      negative association with remission (p=0.007). CONCLUSIONS: Higher 
      disorganization symptoms showed the greatest impact in functioning at acute 
      phase, and prevented patients from achieving remission, suggesting it may be a 
      marker of symptom severity and worse outcome in schizophrenia.
FAU - Ortiz, Bruno Bertolucci
AU  - Ortiz BB
FAU - Gadelha, Ary
AU  - Gadelha A
FAU - Higuchi, Cinthia Hiroko
AU  - Higuchi CH
FAU - Noto, Cristiano
AU  - Noto C
FAU - Medeiros, Daiane
AU  - Medeiros D
FAU - Pitta, Jose Cassio do Nascimento
AU  - Pitta JCDN
FAU - de Araujo Filho, Gerardo Maria
AU  - de Araujo Filho GM
FAU - Hallak, Jaime Eduardo Cecilio
AU  - Hallak JEC
FAU - Bressan, Rodrigo Affonseca
AU  - Bressan RA
LA  - eng
PT  - Journal Article
DEP - 20150224
PL  - United States
TA  - Clin Schizophr Relat Psychoses
JT  - Clinical schizophrenia & related psychoses
JID - 101312513
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Remission Induction
MH  - Schizophrenia/*physiopathology/therapy
MH  - *Severity of Illness Index
OTO - NOTNLM
OT  - Disorganized Schizophrenia
OT  - Functional Remission
OT  - Remission in Schizophrenia
OT  - Symptom Dimensions
EDAT- 2015/02/26 06:00
MHDA- 2017/11/29 06:00
CRDT- 2015/02/26 06:00
PHST- 2015/02/26 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2015/02/26 06:00 [entrez]
AID - 287485376K756242 [pii]
AID - 10.3371/CSRP.ORGA.022015 [doi]
PST - ppublish
SO  - Clin Schizophr Relat Psychoses. 2017 Fall;11(3):151-155. doi: 
      10.3371/CSRP.ORGA.022015. Epub 2015 Feb 24.