PMID- 2571175
OWN - NLM
STAT- MEDLINE
DCOM- 19891025
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 99
IP  - 1
DP  - 1989
TI  - A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA.
PG  - 40-7
AB  - Methylenedioxymethamphetamine (MDMA) is a phenylethylamine with a chemical 
      structure that resembles both the amphetamines and mescaline and has both 
      stimulant and perception altering properties. The stimulant properties of MDMA 
      were assessed in photocell cages designed to measure locomotor activity in rats. 
      MDMA, over a range of doses (2.5-10.0 mg/kg, SC) produced locomotor hyperactivity 
      which lasted up to 4 h. Further studies examined the role of the mesolimbic 
      dopamine system in the hyperactivity induced by MDMA. 6-Hydroxydopamine lesions 
      of the Nucleus accumbens attenuated the locomotor response produced by MDMA. The 
      well characterized attenuation of the locomotor response produced by amphetamine 
      was also demonstrated in the same rats. The present study demonstrates 
      similarities in the stimulant properties of MDMA and amphetamine, and also 
      suggests that as with amphetamine, the locomotor activation associated with MDMA 
      may involve the presynaptic release of dopamine in the region of the Nucleus 
      accumbens. However, MDMA may have a more unusual pharmacological profile because 
      of its longer duration of action, neurotoxic potential, and differences in the 
      qualitative aspects of its psychoactive effects.
FAU - Gold, L H
AU  - Gold LH
AD  - Department of Basic and Clinical Research, Research Institute of Scripps Clinic, 
      La Jolla, CA 92037.
FAU - Hubner, C B
AU  - Hubner CB
FAU - Koob, G F
AU  - Koob GF
LA  - eng
GR  - DA 04043/DA/NIDA NIH HHS/United States
GR  - DA 05292/DA/NIDA NIH HHS/United States
GR  - DA 05333/DA/NIDA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Amphetamines)
RN  - 0 (Hydroxydopamines)
RN  - 0 (Psychotropic Drugs)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - CK833KGX7E (Amphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - TG537D343B (Desipramine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamine/pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Desipramine/pharmacology
MH  - Dopamine/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Hydroxydopamines
MH  - Male
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Nucleus Accumbens/*drug effects
MH  - Oxidopamine
MH  - Psychotropic Drugs/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Dopamine/drug effects
MH  - Receptors, Serotonin/drug effects
MH  - Septal Nuclei/*drug effects
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1007/BF00634450 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1989;99(1):40-7. doi: 10.1007/BF00634450.