PMID- 25712618
OWN - NLM
STAT- MEDLINE
DCOM- 20160211
LR  - 20240330
IS  - 1544-2241 (Electronic)
IS  - 1544-1873 (Print)
IS  - 1544-1873 (Linking)
VI  - 13
IP  - 3
DP  - 2015 Jun
TI  - IL-6 and IGF-1 Signaling Within and Between Muscle and Bone: How Important is the 
      mTOR Pathway for Bone Metabolism?
PG  - 131-9
LID - 10.1007/s11914-015-0264-1 [doi]
AB  - Insulin-like growth factor 1 (IGF-1) and interleukin 6 (IL-6) play an important 
      role in the adaptation of both muscle and bone to mechanical stimuli. Here, we 
      provide an overview of the functions of IL-6 and IGF-1 in bone and muscle 
      metabolism, and the intracellular signaling pathways that are well known to 
      mediate these functions. In particular, we discuss the Akt/mammalian target of 
      rapamycin (mTOR) pathway which in skeletal muscle is known for its key role in 
      regulating the rate of mRNA translation (protein synthesis). Since the role of 
      the mTOR pathway in bone is explored to a much lesser extent, we discuss what is 
      known about this pathway in bone and the potential role of this pathway in bone 
      remodeling. We will also discuss the possible ways of influencing IGF-1 or IL-6 
      signaling by osteocytes and the clinical implications of pharmacological or 
      nutritional modulation of the Akt/mTOR pathway.
FAU - Bakker, Astrid D
AU  - Bakker AD
AD  - Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), 
      University of Amsterdam and VU University Amsterdam, MOVE Research Institute 
      Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands, 
      a.bakker@acta.nl.
FAU - Jaspers, Richard T
AU  - Jaspers RT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Osteoporos Rep
JT  - Current osteoporosis reports
JID - 101176492
RN  - 0 (Interleukin-6)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adaptation, Physiological/physiology
MH  - Animals
MH  - Biomechanical Phenomena/physiology
MH  - Bone and Bones/*metabolism
MH  - Homeostasis/physiology
MH  - Humans
MH  - Insulin-Like Growth Factor I/*physiology
MH  - Interleukin-6/*physiology
MH  - Muscle, Skeletal/*physiology
MH  - Proto-Oncogene Proteins c-akt/physiology
MH  - Signal Transduction/*physiology
MH  - Stress, Mechanical
MH  - TOR Serine-Threonine Kinases/*physiology
PMC - PMC4417129
COIS- AD Bakker and RT Jaspers both declare no conflicts of interest.
EDAT- 2015/02/26 06:00
MHDA- 2016/02/13 06:00
PMCR- 2015/02/25
CRDT- 2015/02/26 06:00
PHST- 2015/02/26 06:00 [entrez]
PHST- 2015/02/26 06:00 [pubmed]
PHST- 2016/02/13 06:00 [medline]
PHST- 2015/02/25 00:00 [pmc-release]
AID - 264 [pii]
AID - 10.1007/s11914-015-0264-1 [doi]
PST - ppublish
SO  - Curr Osteoporos Rep. 2015 Jun;13(3):131-9. doi: 10.1007/s11914-015-0264-1.