PMID- 25713503
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150225
LR  - 20201001
IS  - 1598-2629 (Print)
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Linking)
VI  - 15
IP  - 1
DP  - 2015 Feb
TI  - Regulation of intestinal immune system by dendritic cells.
PG  - 1-8
LID - 10.4110/in.2015.15.1.1 [doi]
AB  - Innate immune cells survey antigenic materials beneath our body surfaces and 
      provide a front-line response to internal and external danger signals. Dendritic 
      cells (DCs), a subset of innate immune cells, are critical sentinels that perform 
      multiple roles in immune responses, from acting as principal modulators to 
      priming an adaptive immune response through antigen-specific signaling. In the 
      gut, DCs meet exogenous, non-harmful food antigens as well as vast commensal 
      microbes under steady-state conditions. In other instances, they must combat 
      pathogenic microbes to prevent infections. In this review, we focus on the 
      function of intestinal DCs in maintaining intestinal immune homeostasis. 
      Specifically, we describe how intestinal DCs affect IgA production from B cells 
      and influence the generation of unique subsets of T cell.
FAU - Ko, Hyun-Jeong
AU  - Ko HJ
AD  - Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National 
      University, Chuncheon 200-701, Korea.
FAU - Chang, Sun-Young
AU  - Chang SY
AD  - Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon 443-749, 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150217
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC4338263
OTO - NOTNLM
OT  - Dendritic cells
OT  - Gut
OT  - Regulatory T cells
OT  - Secretory IgA
OT  - Th17
COIS- The authors have no financial conflict of interest.
EDAT- 2015/02/26 06:00
MHDA- 2015/02/26 06:01
PMCR- 2015/02/01
CRDT- 2015/02/26 06:00
PHST- 2014/11/25 00:00 [received]
PHST- 2015/01/05 00:00 [revised]
PHST- 2015/01/08 00:00 [accepted]
PHST- 2015/02/26 06:00 [entrez]
PHST- 2015/02/26 06:00 [pubmed]
PHST- 2015/02/26 06:01 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - 10.4110/in.2015.15.1.1 [doi]
PST - ppublish
SO  - Immune Netw. 2015 Feb;15(1):1-8. doi: 10.4110/in.2015.15.1.1. Epub 2015 Feb 17.