PMID- 25713781
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150225
LR  - 20201001
IS  - 2227-684X (Print)
IS  - 2227-8575 (Electronic)
IS  - 2227-684X (Linking)
VI  - 4
IP  - 1
DP  - 2015 Feb
TI  - Management of pancreatic neuroendocrine tumors in patients with MEN 1.
PG  - 63-8
LID - 10.3978/j.issn.2227-684X.2014.12.01 [doi]
AB  - Pancreatic neuroendocrine tumors (PNETs) are frequent and can be non-functional 
      (NF) in patients with multiple endocrine neoplasia type 1 (MEN1). Their 
      identification is of clinical importance because malignant PNETs are reported to 
      be the most common cause of death in patients with MEN1. Once the diagnosis of 
      MEN1 is established in an individual based on clinical manifestations and/or 
      genetic testing results, an active surveillance program is instituted for early 
      detection and treatment of MEN1-associated disease. Ultrasonography, endoscopic 
      ultrasonography (EUS), CT, MRI, selective arterial angiography and somatostatin 
      receptor scintigraphy are all used for localization of tumors. Managing PNETs can 
      be challenging and includes diagnosis, surveillance, adequate staging, and 
      interdisciplinary, multimodal treatments to optimize patient outcome. Treatment 
      includes surgical resection for loco-regional disease, as well as liver directed 
      and targeted chemotherapies for advanced progressive disease. To date, the 
      recommendation for surgical resection in NF-PNETs is based on tumor size, as a 
      higher rate of metastases was found in patients with larger tumors. This review 
      summarizes key concepts in managing PNETs in patients with MEN1.
FAU - Sadowski, Samira M
AU  - Sadowski SM
AD  - 1 Endocrine Oncology Branch, National Institutes of Health, Bethesda, MD 20892, 
      USA ; 2 Thoracic and Endocrine Surgery, University Hospitals of Geneva, 1211 
      Geneva, Switzerland.
FAU - Triponez, Frederic
AU  - Triponez F
AD  - 1 Endocrine Oncology Branch, National Institutes of Health, Bethesda, MD 20892, 
      USA ; 2 Thoracic and Endocrine Surgery, University Hospitals of Geneva, 1211 
      Geneva, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China (Republic : 1949- )
TA  - Gland Surg
JT  - Gland surgery
JID - 101606638
PMC - PMC4321051
OTO - NOTNLM
OT  - Pancreatic neuroendocrine tumors (PNETs)
OT  - multiple endocrine neoplasia type 1 (MEN1)
OT  - surgical management
EDAT- 2015/02/26 06:00
MHDA- 2015/02/26 06:01
PMCR- 2015/02/01
CRDT- 2015/02/26 06:00
PHST- 2014/11/11 00:00 [received]
PHST- 2014/11/28 00:00 [accepted]
PHST- 2015/02/26 06:00 [entrez]
PHST- 2015/02/26 06:00 [pubmed]
PHST- 2015/02/26 06:01 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - gs-04-01-063 [pii]
AID - 10.3978/j.issn.2227-684X.2014.12.01 [doi]
PST - ppublish
SO  - Gland Surg. 2015 Feb;4(1):63-8. doi: 10.3978/j.issn.2227-684X.2014.12.01.