PMID- 25714755
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20181218
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Linking)
VI  - 37
IP  - 2
DP  - 2015 Apr-Jun
TI  - Serum concentrations of brain-derived neurotrophic factor and mental disorders in 
      imprisoned women.
PG  - 113-20
LID - S1516-44462015005041421 [pii]
LID - 10.1590/1516-4446-2014-1421 [doi]
AB  - OBJECTIVE: Mental disorders and early trauma are highly prevalent in female 
      inmates. Brain-derived neurotrophic factor (BDNF) plays an important role in 
      learning, memory processes, and mood regulation. The aim of this study was to 
      evaluate the relationship between serum BDNF levels and mental disorders among 
      imprisoned women as compared with age- and education-matched controls. METHODS: A 
      consecutively recruited sample of 18 female prisoners with mental disorders was 
      assessed for sociodemographic, criminal, and clinical variables using 
      standardized instruments, the Mini International Neuropsychiatric Interview Plus 
      (MINI Plus), and serum BDNF levels. RESULTS: High rates of childhood sexual abuse 
      and posttraumatic stress disorder (PTSD) were found in the group of forensic 
      patients. Serum BDNF levels in the forensic group did not differ from those of 
      healthy controls, and were significantly higher when compared with those of women 
      with mental disorders hospitalized in a general hospital. CONCLUSION: Elevated 
      serum BDNF levels were found in imprisoned women. The results of this study may 
      suggest neurobiological mechanisms similar to those seen in previous clinical and 
      preclinical studies showing the involvement of BDNF in the pathophysiology of 
      PTSD.
FAU - Dotta-Panichi, Renata M
AU  - Dotta-Panichi RM
AD  - Graduate Program in Health Sciences, Universidade Federal de Ciencias da Saude de 
      Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
FAU - Bins, Helena D
AU  - Bins HD
AD  - Graduate Program in Health Sciences, Universidade Federal de Ciencias da Saude de 
      Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil.
FAU - Tramontina, Juliana F
AU  - Tramontina JF
AD  - Department of Clinical Medicine, UFCSPA, Porto Alegre, RS, Brazil.
FAU - Cereser, Keila M
AU  - Cereser KM
AD  - Graduate Program in Medical Sciences: Psychiatry, Universidade Federal do Rio 
      Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
FAU - Aguiar, Bianca W de
AU  - Aguiar BW
AD  - Graduate Program in Biological Sciences: Biochemistry, Porto Alegre, Brazil.
FAU - Paz, Andre C
AU  - Paz AC
AD  - Laboratory of Molecular Psychiatry, UFRGS, Porto Alegre, RS, Brazil.
FAU - Taborda, Jose G
AU  - Taborda JG
AD  - Department of Clinical Medicine, UFCSPA, Porto Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150224
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Brazil
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Prisoners
MH  - Prisons
MH  - Socioeconomic Factors
MH  - Stress Disorders, Post-Traumatic/*blood/classification
MH  - Young Adult
EDAT- 2015/02/26 06:00
MHDA- 2016/01/26 06:00
CRDT- 2015/02/26 06:00
PHST- 2014/04/02 00:00 [received]
PHST- 2014/07/27 00:00 [accepted]
PHST- 2015/02/26 06:00 [entrez]
PHST- 2015/02/26 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
AID - S1516-44462015005041421 [pii]
AID - 10.1590/1516-4446-2014-1421 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2015 Apr-Jun;37(2):113-20. doi: 10.1590/1516-4446-2014-1421. 
      Epub 2015 Feb 24.