PMID- 25714877
OWN - NLM
STAT- MEDLINE
DCOM- 20160307
LR  - 20181113
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 11
IP  - 3
DP  - 2015
TI  - Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and 
      Vibrio aestuarianus infections.
PG  - 516-26
LID - 10.1080/15548627.2015.1017188 [doi]
AB  - Recent mass mortality outbreaks around the world in Pacific oysters, Crassostrea 
      gigas, have seriously affected the aquaculture economy. Although the causes for 
      these mortality outbreaks appear complex, infectious agents are involved. Two 
      pathogens are associated with mass mortality outbreaks, the virus ostreid 
      herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe 
      the interactions between these 2 pathogens and autophagy, a conserved 
      intracellular pathway playing a key role in innate immunity. We show for the 
      first time that autophagy pathway is present and functional in Pacific oysters 
      and plays an important role to protect animals from infections. This study 
      contributes to better understand the innate immune system of Pacific oysters.
FAU - Moreau, Pierrick
AU  - Moreau P
AD  - a Ifremer (Institut Francais de Recherche pour l'Exploitation de la Mer); 
      Laboratoire de Genetique et Pathologie des Mollusques Marins; Ronce Les Bains ; 
      La Tremblade , France.
FAU - Moreau, Kevin
AU  - Moreau K
FAU - Segarra, Amelie
AU  - Segarra A
FAU - Tourbiez, Delphine
AU  - Tourbiez D
FAU - Travers, Marie-Agnes
AU  - Travers MA
FAU - Rubinsztein, David C
AU  - Rubinsztein DC
FAU - Renault, Tristan
AU  - Renault T
LA  - eng
GR  - 095317/Wellcome Trust/United Kingdom
GR  - 100140/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Aquaculture
MH  - *Autophagy
MH  - Bacterial Infections/immunology/veterinary
MH  - Crassostrea/*immunology/*microbiology/*virology
MH  - DNA, Viral/isolation & purification
MH  - Gene Expression Regulation
MH  - Herpesviridae/*pathogenicity
MH  - Immunity, Innate
MH  - Microscopy, Electron, Transmission
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Real-Time Polymerase Chain Reaction
MH  - Signal Transduction
MH  - Vibrio/*pathogenicity
MH  - Virus Diseases/immunology/veterinary
PMC - PMC4502751
OTO - NOTNLM
OT  - ATG, autophagy-related
OT  - Atg8-PE, Atg8-phosphatidylethenolamine
OT  - Crassostrea gigas
OT  - DNA, deoxyribonucleic acid
OT  - LC3-II, cleaved, lipidated and autophagosome-associated form of LC3
OT  - MAP1LC3A/B (LC3A/B), microtubule-associated proteins 1 light chain 3 alpha/beta 
      (mammalian orthologs of the predicted Crassostrea gigas LC3 and yeast Atg8)
OT  - NH4Cl, ammonium chloride
OT  - OsHV-1
OT  - OsHV-1, Ostreid herpesvirus 1
OT  - PCR, polymerase chain reaction
OT  - Pacific oyster
OT  - Vibrio aestuarianus
OT  - autophagy
OT  - hpi, hours postinfection
EDAT- 2015/02/26 06:00
MHDA- 2016/03/08 06:00
PMCR- 2016/02/03
CRDT- 2015/02/26 06:00
PHST- 2015/02/26 06:00 [entrez]
PHST- 2015/02/26 06:00 [pubmed]
PHST- 2016/03/08 06:00 [medline]
PHST- 2016/02/03 00:00 [pmc-release]
AID - 1017188 [pii]
AID - 10.1080/15548627.2015.1017188 [doi]
PST - ppublish
SO  - Autophagy. 2015;11(3):516-26. doi: 10.1080/15548627.2015.1017188.