PMID- 25721364
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20150317
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 65
IP  - 2
DP  - 2015 Jun
TI  - Annotation and genetic diversity of the chicken collagenous lectins.
PG  - 277-86
LID - S0161-5890(15)00037-1 [pii]
LID - 10.1016/j.molimm.2015.01.027 [doi]
AB  - Collectins and ficolins are multimeric proteins present in various tissues and 
      are actively involved in innate immune responses. In chickens, six different 
      collagenous lectins have been characterized so far: mannose-binding lectin (MBL), 
      surfactant protein A (SP-A), collectin 10 (COLEC10), collectin 11 (COLEC11), 
      collectin 12 (COLEC12), lung lectin (LL) and one ficolin (FCN). However, the 
      structural and functional features of the chicken collectins and ficolin are 
      still not fully understood. Therefore, the aims of this study were: (i) to make 
      an overview of the genetic structure and function of chicken collectins and the 
      ficolin, (ii) to investigate the variation in the chicken collectins and the 
      ficolin gene in different chicken populations, and (iii) to assess the presence 
      of MBL gene variants in different chicken populations. We performed comparative 
      genomic analysis using publically available data. The obtained results showed 
      that collectins and ficolins have conserved protein sequences and gene structure 
      across all vertebrate groups and this is especially notable for COLEC10, COLEC11 
      and COLEC12. For the purpose of studying the genetic variation, 179 animals from 
      14 populations were genotyped using 31 SNPs covering five genomic regions. The 
      obtained results revealed low level of heterozygosity in the collagenous lectins 
      except for the COLEC12 gene and the LL-SPA-MBL region compared to heterozygosity 
      at neutral microsatellite markers. In addition, the MBL gene variants were 
      assessed in different chicken populations based on the polymorphisms in the 
      promoter region. We observed 10 previously identified MBL variants with A2/A8 and 
      A4 as the most frequent alleles.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Hamzic, Edin
AU  - Hamzic E
AD  - AgroParisTech, UMR1313 Animal Genetics and Integrative Biology, 16 rue Claude 
      Bernard, 75231 Paris 05, France; INRA, UMR1313 Animal Genetics and Integrative 
      Biology, Domaine de Vilvert, 78350 Jouy-en-Josas, France; Department of Molecular 
      Biology and Genetics, Aarhus University, Blichers Alle 20, Building K23, 8830 
      Tjele, Denmark. Electronic address: edin.hamzic@jouy.inra.fr.
FAU - Pinard-van der Laan, Marie-Helene
AU  - Pinard-van der Laan MH
AD  - INRA, UMR1313 Animal Genetics and Integrative Biology, Domaine de Vilvert, 78350 
      Jouy-en-Josas, France; AgroParisTech, UMR1313 Animal Genetics and Integrative 
      Biology, 16 rue Claude Bernard, 75231 Paris 05, France. Electronic address: 
      marie-helene.pinard@jouy.inra.fr.
FAU - Bed'Hom, Bertrand
AU  - Bed'Hom B
AD  - INRA, UMR1313 Animal Genetics and Integrative Biology, Domaine de Vilvert, 78350 
      Jouy-en-Josas, France; AgroParisTech, UMR1313 Animal Genetics and Integrative 
      Biology, 16 rue Claude Bernard, 75231 Paris 05, France. Electronic address: 
      bertrand.bedhom@jouy.inra.fr.
FAU - Juul-Madsen, Helle Risdahl
AU  - Juul-Madsen HR
AD  - Department of Animal Science, Aarhus University, Blichers Alle 20, Building P25, 
      8830 Tjele, Denmark. Electronic address: helle.juulmadsen@anis.au.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150224
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Avian Proteins)
RN  - 0 (Collectins)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Avian Proteins/*genetics/immunology
MH  - Chickens/*genetics/immunology
MH  - Collectins/*genetics/immunology
MH  - *Databases, Nucleic Acid
MH  - Gene Frequency/immunology
MH  - Heterozygote
MH  - Microsatellite Repeats/immunology
MH  - *Molecular Sequence Annotation
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Chicken
OT  - Collectins
OT  - Ficolins
OT  - Genotyping
OT  - Immunogenetics
OT  - Innate immunity
EDAT- 2015/02/28 06:00
MHDA- 2015/05/12 06:00
CRDT- 2015/02/28 06:00
PHST- 2014/11/10 00:00 [received]
PHST- 2015/01/26 00:00 [revised]
PHST- 2015/01/30 00:00 [accepted]
PHST- 2015/02/28 06:00 [entrez]
PHST- 2015/02/28 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - S0161-5890(15)00037-1 [pii]
AID - 10.1016/j.molimm.2015.01.027 [doi]
PST - ppublish
SO  - Mol Immunol. 2015 Jun;65(2):277-86. doi: 10.1016/j.molimm.2015.01.027. Epub 2015 
      Feb 24.